Key Laboratory of Bionic Engineering, Ministry of Education, Jilin University, Changchun 130022, China.
School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China.
J Hazard Mater. 2022 Jun 15;432:128685. doi: 10.1016/j.jhazmat.2022.128685. Epub 2022 Mar 11.
Constructing safe and effective antibacterial surfaces has continuously received great attention, especially in healthcare-related fields. Bioinspired mechano-bactericidal nanostructure surfaces could serve as a promising strategy to reduce surface bacterial contamination while avoiding the development of antibiotic resistance. Although effective, these nanostructure surfaces are prone to be contaminated by the accumulation of dead bacteria, inevitably compromising their long-term antibacterial activity. Herein, a bioinspired nanopillar surface with both mechano-bactericidal and releasing actions is developed, via grafting zwitterionic polymer (poly(sulfobetaine methacrylate) (PSBMA)) on ZnO nanopillars. Under dry conditions, this nanopillar surface displays remarkable mechano-bactericidal activity, because the collapsed zwitterionic polymer layer makes no essential influence on nanopillar structure. Once being incubated with aqueous solution, the surface could readily detach the killed bacteria and debris, owing to the swelling of the zwitterionic layer. Consequentially, the surface antibacterial performances can be rapidly and controllably switched between mechano-bactericidal action and bacteria-releasing activity, guaranteeing a long-lasting antibacterial performance. Notably, these collaborative antibacterial behaviors are solely based on physical actions, avoiding the risk of triggering bacteria resistance. The resultant nanopillar surface also enjoys the advantages of substrate-independency and good biocompatibility, offering potential antibacterial applications for biomedical devices and hospital surfaces.
构建安全有效的抗菌表面一直受到极大关注，特别是在与医疗保健相关的领域。仿生机械杀菌纳米结构表面可以作为一种很有前途的策略，既能减少表面细菌污染，又能避免抗生素耐药性的产生。尽管这些纳米结构表面非常有效，但它们容易因死亡细菌的积累而受到污染，从而不可避免地降低其长期的抗菌活性。在此，通过在 ZnO 纳米柱上接枝两性离子聚合物（聚（磺酸甜菜碱甲基丙烯酸酯）（PSBMA）），开发了一种具有机械杀菌和释放作用的仿生纳米柱表面。在干燥条件下，这种纳米柱表面表现出显著的机械杀菌活性，因为坍塌的两性离子聚合物层对纳米柱结构没有本质影响。一旦与水溶液孵育，由于两性离子层的溶胀，表面可以很容易地分离出被杀灭的细菌和碎片。因此，表面的抗菌性能可以在机械杀菌作用和细菌释放作用之间快速、可控地切换，从而保证持久的抗菌性能。值得注意的是，这些协同的抗菌行为完全基于物理作用，避免了引发细菌耐药性的风险。所得的纳米柱表面还具有基底独立性和良好的生物相容性的优点，为生物医学设备和医院表面提供了潜在的抗菌应用。
