Poulsen S S, Nexø E, Olsen P S, Hess J, Kirkegaard P
Histochemistry. 1986;85(5):389-94. doi: 10.1007/BF00982668.
Epidermal growth factor (EGF) is a peptide which stimulates cell mitotic activity and differentiation, has a cytoprotective effect on the gastroduodenal mucosa, and inhibits gastric acid secretion. The immunohistochemical localization of EGF in the Brunner's glands and the submandibular glands is well documented. The localization of EGF in other tissues is still unclarified. In the present study, the immunohistochemical localization of EGF in tissues from rat, man and a 20 week human fetus were investigated. In man and rat, immunoreaction was found in the submandibular glands, the serous glands of the nasal cavity, Brunner's glands of the duodenum, the Paneth cells of the small intestine, and the tubular cells of the kidney. In the fetus EGF was found in the kidney and in the intestinal Paneth cells. Antisera raised against rat submandibular EGF did not recognize EGF in human tissues, whereas antisera against human urinary EGF worked in rat as well as man. EGF was found only in cells with an exocrine function.
表皮生长因子（EGF）是一种能刺激细胞有丝分裂活性和分化的肽，对胃十二指肠黏膜具有细胞保护作用，并能抑制胃酸分泌。EGF在十二指肠腺和下颌下腺中的免疫组织化学定位已有充分记录。EGF在其他组织中的定位仍不明确。在本研究中，对大鼠、人类以及20周龄人类胎儿组织中EGF的免疫组织化学定位进行了研究。在人类和大鼠中，在下颌下腺、鼻腔浆液腺、十二指肠的十二指肠腺、小肠的潘氏细胞以及肾的肾小管细胞中发现了免疫反应。在胎儿中，在肾脏和肠道潘氏细胞中发现了EGF。针对大鼠下颌下EGF产生的抗血清不能识别人类组织中的EGF，而针对人类尿液EGF的抗血清在大鼠和人类中均起作用。EGF仅在具有外分泌功能的细胞中发现。
