Department of Plastic and Cosmetic Surgery, The Central Hospital of Yueyang, Yueyang, Hunan 414000, China.
Department of Burn and Plastic Surgery, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421000, China.
J Healthc Eng. 2022 Mar 24;2022:6590025. doi: 10.1155/2022/6590025. eCollection 2022.
The aim of this pilot clinical study is to evaluate the efficacy of human adipose derived mesenchymal stem cells (HAMSCs) treatment for the wound healing with patients.
This study was a clinical trial to investigate the efficacy of human adipose derived mesenchymal stem cells treatment for the wound healing with patients. 346 patients with skin wounds attending the central hospital of Yue Yang were enrolled in the study, setting in the period from January 2016 to January 2021. Patients were randomly allocated into two groups: experimental group received treatment with human adipose derived mesenchymal stem cells for each 10 cm of wound and control group received conventional dressing with normal saline for each 10 cm of wound.
No adverse events were recorded during the period of treatment. The granulation tissue coverage rate and thickness of granulation tissue after 10 days of treatment in experimental group were significantly improved compared with control group. Furthermore, the occurrence of bleeding of wound and suppurative wounds between two groups had significant difference ( < 0.05).
The data in this pilot study indicated that human adipose derived mesenchymal stem cells may be a safe and effective alternative therapy for wound healing. Moreover, larger, placebo-controlled, perspective studies are necessity to evaluate the efficacy and safety of human adipose derived mesenchymal stem cells treatment for wound healing patients.
本研究旨在评估人脂肪间充质干细胞（HAMSCs）治疗患者伤口愈合的疗效。
本研究为临床试验，旨在研究人脂肪间充质干细胞治疗患者伤口愈合的疗效。岳阳中心医院收治的 346 例皮肤伤口患者纳入本研究，研究时间为 2016 年 1 月至 2021 年 1 月。患者随机分为两组：实验组每 10cm 伤口接受人脂肪间充质干细胞治疗，对照组每 10cm 伤口接受生理盐水常规换药。
治疗期间未发生不良事件。实验组治疗 10 天后肉芽组织覆盖率和肉芽组织厚度明显优于对照组。此外，两组伤口出血和化脓性伤口的发生率有显著差异（<0.05）。
本研究初步数据表明，人脂肪间充质干细胞可能是治疗伤口愈合的一种安全有效的替代疗法。此外，还需要更大规模、安慰剂对照、前瞻性研究来评估人脂肪间充质干细胞治疗伤口愈合患者的疗效和安全性。
