Ratanapob Niorn, Thuamsuwan Nattanan, Thongyuan Suporn
Department of Large Animal and Wildlife Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Malaiman Road, Kamphaeng Saen, Nakhon Pathom, Thailand.
Sing Buri Provincial Livestock Office, Department of Livestock Development, Sing Buri-Suphan Buri Road, Ton Pho, Mueang district, Sing Buri, Thailand.
Vet World. 2022 Jan;15(1):83-90. doi: 10.14202/vetworld.2022.83-90. Epub 2022 Jan 20.
Promotions of goat farming by both public and private sectors encouraged considerable goat raising in central Thailand. Gastrointestinal nematodes (GIN) infection is a major health and economic problem; however, evidence of resistance to broad-spectrum anthelmintics is frequently reported. Investigation of anthelmintic resistance (AR) status and identification of factors related to the development of AR is important components for sustainable GIN control. However, no information is available on this topic in the study area. The present study aimed to gather information on GIN control practices and to evaluate the effectiveness of albendazole, ivermectin, and levamisole for treating GIN infestation in goat herds in Sing Buri Province.
Twenty-nine herds were randomly selected. Information on management practices was collected by face-to-face interview using a structured questionnaire. Three field experiments for routinely used anthelmintics, including albendazole, ivermectin, and levamisole were conducted from June 2019 to November 2019. Fecal samples were collected pre- and post-treatment and examined for fecal egg count reduction to determine the status of anthelmintic resistance of goat GIN.
Several improper practices were identified that lead to AR, especially chronic use of albendazole and ivermectin. All herds were considered resistant to albendazole and ivermectin, and levamisole resistant nematodes were detected in two herds. AR was strongly linked with the continuous use of anthelmintics.
Levamisole, which was still effective in the province, should be used with caution to minimize the selection of resistant strains. Farmers should be provided with updated information for sustainable parasite control. Further, the efficacy of anthelmintics should be routinely monitored.
公共和私营部门对山羊养殖的推广促使泰国中部地区的山羊养殖规模大幅增长。胃肠道线虫（GIN）感染是一个主要的健康和经济问题；然而，对广谱驱虫药产生抗药性的证据屡见不鲜。调查驱虫药抗药性（AR）状况并确定与AR发展相关的因素是可持续控制GIN的重要组成部分。然而，研究区域内尚无关于该主题的信息。本研究旨在收集有关GIN控制措施的信息，并评估阿苯达唑、伊维菌素和左旋咪唑对信武里府山羊群中GIN感染的治疗效果。
随机选取29个山羊群。通过使用结构化问卷进行面对面访谈收集管理措施方面的信息。2019年6月至2019年11月，对常用驱虫药阿苯达唑、伊维菌素和左旋咪唑进行了三项田间试验。在治疗前后采集粪便样本，并检查粪便虫卵计数减少情况，以确定山羊GIN的驱虫药抗药性状况。
发现了几种导致AR的不当做法，尤其是长期使用阿苯达唑和伊维菌素。所有山羊群都被认为对阿苯达唑和伊维菌素有抗药性，并且在两个山羊群中检测到了对左旋咪唑有抗药性的线虫。AR与持续使用驱虫药密切相关。
在该省仍有效的左旋咪唑应谨慎使用，以尽量减少耐药菌株的选择。应向农民提供最新信息以实现寄生虫的可持续控制。此外，应定期监测驱虫药的疗效。
