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塞内加尔早期的新冠病毒疫情是由B.1.416毒株在当地出现以及欧洲的B.1.1.420毒株传入所引发的。

The early SARS-CoV-2 epidemic in Senegal was driven by the local emergence of B.1.416 and the introduction of B.1.1.420 from Europe.

作者信息

Perez Lester J, Orf Gregory S, Berg Michael G, Rodgers Mary A, Meyer Todd V, Mohaimani Aurash, Olivo Ana, Harris Barbara, Mowerman Illya, Padane Abdou, Dela-Del Lawson Agbogbenkou Tevi, Mboup Aminata, Mbow Moustapha, Leye Nafissatou, Touré-Kane Ndeye Coumba, Ahouidi Ambroise D, Cloherty Gavin A, Mboup Souleymane

机构信息

Infectious Disease Core Research, Abbott Diagnostics Division, Abbott Laboratories, 100 Abbott Park Rd, Lake Bluff, IL 60044, USA.

Institut de Recherche en Santé de Surveillance Épidémiologique et de Formation, 4 Rue 2 D1 Pole Urbain de Diamniado, Dakar BP 7325, Senegal.

出版信息

Virus Evol. 2022 Mar 21;8(1):veac025. doi: 10.1093/ve/veac025. eCollection 2022.

DOI:10.1093/ve/veac025
PMID:35371561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8971539/
Abstract

Molecular surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing in west Africa, especially in the Republic of Senegal. Here, we present a molecular epidemiology study of the early waves of SARS-CoV-2 infections in this country based on Bayesian phylogeographic approaches. Whereas the first wave in mid-2020 was characterized by a significant diversification of lineages and predominance of B.1.416, the second wave in late 2020 was composed primarily of B.1.1.420. Our results indicate that B.1.416 originated in Senegal and was exported mainly to Europe. In contrast, B.1.1.420 was introduced from Italy, gained fitness in Senegal, and then spread worldwide. Since both B.1.416 and B.1.1.420 lineages carry several positive selected mutations in the spike and nucleocapsid genes, each of which may explain their local dominance, their mutation profiles should be carefully monitored. As the pandemic continues to evolve, molecular surveillance in all regions of Africa will play a key role in stemming its spread.

摘要

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的分子监测在西非地区日益增多，尤其是在塞内加尔共和国。在此，我们基于贝叶斯系统发育地理学方法，对该国SARS-CoV-2感染的早期波次进行了分子流行病学研究。2020年年中出现的第一波疫情的特点是谱系显著多样化且以B.1.416为主，而2020年末的第二波疫情主要由B.1.1.420组成。我们的结果表明，B.1.416起源于塞内加尔，主要传播到欧洲。相比之下，B.1.1.420是从意大利传入的，在塞内加尔适应环境后，然后传播到全球。由于B.1.416和B.1.1.420谱系在刺突蛋白和核衣壳基因中都携带多个正选择突变，每一个突变都可能解释它们在当地的优势地位，因此应仔细监测它们的突变情况。随着疫情的持续演变，非洲所有地区的分子监测将在遏制疫情传播方面发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/ced1ca162a26/veac025f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/a18d2df2db03/veac025f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/fcaf6d7ff8c3/veac025f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/301839a40b5b/veac025f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/ad6a8eb23646/veac025f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/ced1ca162a26/veac025f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/a18d2df2db03/veac025f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/fcaf6d7ff8c3/veac025f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/301839a40b5b/veac025f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/ad6a8eb23646/veac025f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa2/8971539/ced1ca162a26/veac025f5.jpg

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