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多组学基础

The Essentials of Multiomics.

机构信息

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.

Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC, USA.

出版信息

Oncologist. 2022 Apr 5;27(4):272-284. doi: 10.1093/oncolo/oyab048.

Abstract

Within the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, transcriptomics, proteomics, circulating omics, and artificial intelligence are now commonplace, and this rapid evolution has left us with a significant knowledge gap within the medical community. In this paper, we attempt to bridge that gap and prepare the physician in oncology for multiomics, a group of technologies that have gone from looming on the horizon to become a clinical reality. The era of multiomics is here, and we must prepare ourselves for this exciting new age of cancer medicine.

摘要

在过去的十年中,分子检测科学已经从单一基因和单一蛋白质分析发展到广泛的分子谱分析,作为一种标准的护理方法,迅速从研究转向实践。现在,像基因组学、转录组学、蛋白质组学、循环组学和人工智能这样的术语已经很常见了,这种快速的发展使我们在医学界留下了一个巨大的知识鸿沟。在本文中,我们试图弥合这一差距,让肿瘤学医生为多组学做好准备,多组学是一组已经从地平线上崭露头角的技术,正在成为一种临床现实。多组学的时代已经到来,我们必须为癌症医学的这个令人兴奋的新时代做好准备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3863/8982374/b861d678afab/oyab048f0001.jpg

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