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微小RNA介导的EPHX3低表达与头颈部鳞状细胞癌的不良预后及肿瘤免疫浸润相关。

miRNA-Mediated Low Expression of EPHX3 Is Associated with Poor Prognosis and Tumor Immune Infiltration in Head and Neck Squamous Cell Carcinomas.

作者信息

Ding Shun, Hong Qichao, Duan Tingting, Xu Zhengyang, He Qing, Qiu Dongqin, Li Lin, Yan Jingren, Zhang Qimeng, Mu Zhonglin

机构信息

Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou 570102, China.

Department of Otorhinolaryngology Head and Neck Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China.

出版信息

J Oncol. 2022 Apr 1;2022:7633720. doi: 10.1155/2022/7633720. eCollection 2022.

DOI:10.1155/2022/7633720
PMID:35401746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8993555/
Abstract

The aim of this study was to explore the regulatory role of epoxide hydrolase 3 (EPHX3) in head and neck squamous cell carcinoma (HNSCC) and to analyze its bioinformatic function, as well as, to screen and predict the miRNAs that can regulate EPHX3 expression in HNSCC. We examined the expression profile and prognostic potential of EPHX3 in TCGA and GTEX databases and performed functional enrichment analysis of EPHX3 using string database. Subsequently, we analyzed the regulatory role of miRNAs on EPHX3, including expression analysis, correlation analysis, and survival analysis. In addition, we also used TIMER to investigate the relationship among EPHX3 expression level, immune checkpoints, and immune infiltration in HNSCC. The results of data analysis after TGCA showed that EPHX3 is a key regulator of tumorigenesis in 13 cancers and can be used as a marker of poor prognosis in HNSCC patients. Bioinformatics analysis revealed that miR-4713-3p is a key miRNA of EPHX3 in HNSCC. Together, our findings indicate that EPHX3 exerts its anticancer effects by suppressing tumor immune checkpoint expression and immune cell infiltration. Overall, our data uncovered miRNA-mediated EPHX3 downregulation as a contributor to poor HNSCC prognosis and reduced tumor immune infiltration.

摘要

本研究旨在探讨环氧水解酶3（EPHX3）在头颈部鳞状细胞癌（HNSCC）中的调控作用，分析其生物信息学功能，并筛选和预测可调控HNSCC中EPHX3表达的微小RNA（miRNA）。我们在TCGA和GTEX数据库中检测了EPHX3的表达谱和预后潜力，并使用STRING数据库对EPHX3进行了功能富集分析。随后，我们分析了miRNA对EPHX3的调控作用，包括表达分析、相关性分析和生存分析。此外，我们还使用TIMER研究了HNSCC中EPHX3表达水平、免疫检查点和免疫浸润之间的关系。TGCA数据分析结果显示，EPHX3是13种癌症肿瘤发生的关键调节因子，可作为HNSCC患者预后不良的标志物。生物信息学分析表明，miR-4713-3p是HNSCC中EPHX3的关键miRNA。总之，我们的研究结果表明，EPHX3通过抑制肿瘤免疫检查点表达和免疫细胞浸润发挥抗癌作用。总体而言，我们的数据揭示了miRNA介导的EPHX3下调是HNSCC预后不良和肿瘤免疫浸润减少的一个因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/70cd2212503a/JO2022-7633720.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/ae9837c136c1/JO2022-7633720.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/d9cf519d54c2/JO2022-7633720.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/70cd2212503a/JO2022-7633720.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/ae9837c136c1/JO2022-7633720.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/29a45f0a8a13/JO2022-7633720.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/128c16fe6446/JO2022-7633720.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/caef55e53cd8/JO2022-7633720.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/45f8ce809c8e/JO2022-7633720.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/d1208ef322fb/JO2022-7633720.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/2f528d48c592/JO2022-7633720.007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ff/8993555/70cd2212503a/JO2022-7633720.009.jpg

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