State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang, Guizhou 550025, People's Republic of China.
Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
J Agric Food Chem. 2022 Sep 14;70(36):11019-11030. doi: 10.1021/acs.jafc.1c08383. Epub 2022 Apr 11.
Trifluoromethylpyridine (TFMP) is a biologically active fragment formed by connecting trifluoromethyl and pyridine ring. As a result of its unique physical and chemical properties and outstanding biological activity, a variety of pesticide compounds with the TFMP fragment have been discovered and marketed and have played important roles in crop protection research. It is therefore a timely and valuable task to summarize the rationality on how to create new molecules containing TFMP fragments based on the structure-activity relationships, design mentality, and potential mechanism. This review gives a brief summary on the pesticides containing TFMP fragments in the past 5 years and introduces the latest progress of our group in this field. The aim is to provide readers with a convenient route to touch this topic and hopefully serve some educational purpose for graduate students as well.
三氟甲基吡啶（TFMP）是由三氟甲基和吡啶环连接形成的具有生物活性的片段。由于其独特的物理化学性质和突出的生物活性，已发现并上市了多种含有 TFMP 片段的农药化合物，在作物保护研究中发挥了重要作用。因此，及时而有价值的任务是总结如何根据结构-活性关系、设计思路和潜在机制创建含有 TFMP 片段的新分子的合理性。本综述简要总结了过去 5 年含 TFMP 片段的农药，并介绍了我们小组在这一领域的最新进展。目的是为读者提供一条方便的途径来了解这个课题，并希望对研究生有一定的教育意义。
