West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Nutrients. 2022 Mar 30;14(7):1431. doi: 10.3390/nu14071431.
It has widely been accepted that food restriction (FR) without malnutrition has multiple health benefits. Various calorie restriction (CR) and intermittent fasting (IF) regimens have recently been reported to exert neuroprotective effects in traumatic brain injury (TBI) through variable mechanisms. However, the evidence connecting CR or IF to neuroprotection in TBI as well as current issues remaining in this research field have yet to be reviewed in literature. The objective of our review was therefore to weigh the evidence that suggests the connection between CR/IF with recovery promotion following TBI. Medline, Google Scholar and Web of Science were searched from inception to 25 February 2022. An overwhelming number of results generated suggest that several types of CR/IF play a promising role in promoting post-TBI recovery. This recovery is believed to be achieved by alleviating mitochondrial dysfunction, promoting hippocampal neurogenesis, inhibiting glial cell responses, shaping neural cell plasticity, as well as targeting apoptosis and autophagy. Further, we represent our views on the current issues and provide thoughts on the future direction of this research field.
人们普遍认为，在不营养不良的情况下限制食物摄入（FR）有多种健康益处。最近有报道称，各种热量限制（CR）和间歇性禁食（IF）方案通过不同的机制对创伤性脑损伤（TBI）发挥神经保护作用。然而，将 CR 或 IF 与 TBI 中的神经保护联系起来的证据以及该研究领域目前存在的问题尚未在文献中得到综述。因此，我们的综述旨在权衡表明 CR/IF 与 TBI 后恢复之间存在联系的证据。从建库到 2022 年 2 月 25 日，我们在 Medline、Google Scholar 和 Web of Science 上进行了搜索。大量生成的结果表明，几种类型的 CR/IF 在促进 TBI 后恢复方面发挥着有希望的作用。这种恢复被认为是通过缓解线粒体功能障碍、促进海马神经发生、抑制神经胶质细胞反应、塑造神经细胞可塑性以及靶向细胞凋亡和自噬来实现的。此外，我们还代表了我们对当前问题的看法，并就该研究领域的未来方向提供了一些想法。
