1-吡唑并[3,4-d]嘧啶类化合物的合成及其生物医学应用
1-Pyrazolo[3,4-]pyridines: Synthesis and Biomedical Applications.
机构信息
Grup de Química Farmacèutica, IQS School of Engineering, Universitat Ramon Llull, Via Augusta 390, E-08017 Barcelona, Spain.
出版信息
Molecules. 2022 Mar 30;27(7):2237. doi: 10.3390/molecules27072237.
Pyrazolo[3,4-]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1- and 2-isomers. More than 300,000 1-pyrazolo[3,4-]pyridines have been described which are included in more than 5500 references (2400 patents) up to date. This review will cover the analysis of the diversity of the substituents present at positions N1, C3, C4, C5, and C6, the synthetic methods used for their synthesis, starting from both a preformed pyrazole or pyridine, and the biomedical applications of such compounds.
吡唑并[3,4-d]吡啶是一类杂环化合物，具有两种可能的互变异构形式：1-和 2-异构体。迄今为止，已经描述了超过 300,000 种 1-吡唑并[3,4-d]吡啶，这些化合物被收录在超过 5500 篇参考文献（2400 项专利）中。这篇综述将涵盖对 N1、C3、C4、C5 和 C6 位置上取代基的多样性进行分析，以及用于合成它们的合成方法，包括从预先形成的吡唑或吡啶开始，以及这些化合物的生物医学应用。
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