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Cancer treatments should benefit patients: a common-sense revolution in oncology.

作者信息

Gyawali Bishal, Booth Christopher M

机构信息

Division of Cancer Care and Epidemiology, Queen's University Cancer Research Institute, Kingston, Canada.

Department of Oncology and Department of Public Health Sciences, Queen's University, Kingston, Canada.

出版信息

Nat Med. 2022 Apr;28(4):617-620. doi: 10.1038/s41591-021-01662-6.

DOI:10.1038/s41591-021-01662-6
PMID:35440715
Abstract
摘要

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Challenges and opportunities for cancer clinical trials in low- and middle-income countries.低收入和中等收入国家癌症临床试验面临的挑战与机遇
Nat Cancer. 2020 Feb;1(2):142-145. doi: 10.1038/s43018-020-0030-x.
2
Has the Current Oncology Value Paradigm Forgotten Patients' Time?: Too Little of a Good Thing.当前肿瘤学价值范式是否忽视了患者的时间？：好东西太少了。
JAMA Oncol. 2021 Dec 1;7(12):1757-1758. doi: 10.1001/jamaoncol.2021.3600.
3
Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale (ESMO-MCBS) scoring.
Evidence of clinical benefit of cancer medicines considered for funding in Australia.
澳大利亚考虑资助的癌症药物的临床获益证据。
Int J Technol Assess Health Care. 2024 Nov 14;40(1):e55. doi: 10.1017/S0266462324000576.
4
Pioneering sustainable treatment delivery in childhood leukemia through synchronous telemedicine-A pilot study.通过同步远程医疗在儿童白血病中开展开创性的可持续治疗——一项试点研究。
Int J Cancer. 2025 Mar 15;156(6):1247-1255. doi: 10.1002/ijc.35253. Epub 2024 Nov 9.
5
Design issues with lutetium-177 PSMA-617 registration studies that bias the outcome of the experimental arm reflect an increasing misalignment of contemporary oncology trials with true patient benefit.镥-177 PSMA-617注册研究中的设计问题使实验臂的结果产生偏差，这反映出现代肿瘤学试验与真正的患者获益之间的不一致性日益增加。
BJC Rep. 2024 Jun 24;2(1):45. doi: 10.1038/s44276-024-00065-7.
6
Revisiting 'Hallmarks of Cancer' In Sarcomas.重新审视肉瘤中的“癌症特征”
J Cancer. 2024 Feb 4;15(7):1786-1804. doi: 10.7150/jca.92844. eCollection 2024.
7
Shorter Durations of Anti-HER2 Therapy for Patients with Early-Stage, HER2-Positive Breast Cancer: The Physician Perspective.早期HER2阳性乳腺癌患者抗HER2治疗疗程缩短：医生视角
Curr Oncol. 2023 Dec 14;30(12):10477-10487. doi: 10.3390/curroncol30120763.
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Clinical Trials in Palliative Care: Need for Serious Reckoning.姑息治疗中的临床试验：需要认真反思。
JCO Glob Oncol. 2023 Sep;9:e2300181. doi: 10.1200/GO.23.00181.
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Foot health and quality of life in women with breast cancer undergoing chemotherapy: a cross-sectional study.乳腺癌化疗女性的足部健康和生活质量：一项横断面研究。
J Foot Ankle Res. 2023 Aug 21;16(1):52. doi: 10.1186/s13047-023-00650-y.
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The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention.癌症进展中的线粒体ATP合酶/IF1轴：治疗干预靶点
Cancers (Basel). 2023 Jul 25;15(15):3775. doi: 10.3390/cancers15153775.
研究设计、实施和数据分析中的偏倚会扭曲对临床获益的评估和 ESMO-MCBS 评分。
ESMO Open. 2021 Jun;6(3):100117. doi: 10.1016/j.esmoop.2021.100117. Epub 2021 Apr 20.
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Evolution of the Randomized Clinical Trial in the Era of Precision Oncology.精准肿瘤学时代的随机临床试验演变。
JAMA Oncol. 2021 May 1;7(5):728-734. doi: 10.1001/jamaoncol.2021.0379.
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Am Soc Clin Oncol Educ Book. 2019 Jan;39:374-387. doi: 10.1200/EDBK_242229. Epub 2019 May 17.
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Lancet Oncol. 2017 Jul;18(7):887-894. doi: 10.1016/S1470-2045(17)30415-1. Epub 2017 Jun 2.