Souyoul Skylar A, Saussy Katharine P, Lupo Mary P
Lupo Center for Aesthetic and General Dermatology, New Orleans, LA, USA.
Department of Internal Medicine, Tulane University, New Orleans, LA, USA.
Dermatol Ther (Heidelb). 2018 Mar;8(1):5-16. doi: 10.1007/s13555-018-0221-x. Epub 2018 Feb 6.
Skin aging is continuously influenced by various internal and external factors such as the biologic progression of cells, ultraviolet (UV) radiation, tobacco, nutritional deficiencies, and hormonal imbalances that lead to the degradation of skin cells. Through the degradation of skin cells, free radicals and inflammation weaken repair mechanisms and result in collagen and elastic fiber breakdown. The appearance of aging skin is highlighted by skin roughness, wrinkling, pigmentation change, telangiectasias, loss of elasticity, and decreased firmness, all of which are accelerated by these internal and external factors. Throughout the years, nutraceuticals have been studied to delay and fight against these internal and external factors, many of which are found in foods and byproducts consumed naturally. The aim of this review is to aid dermatologists in understanding the mechanism of action of popular nutraceuticals and their possible efficacy in antiaging and skin health.
皮肤老化不断受到各种内部和外部因素的影响，如细胞的生物学进程、紫外线（UV）辐射、烟草、营养缺乏以及激素失衡，这些因素会导致皮肤细胞退化。通过皮肤细胞的退化，自由基和炎症会削弱修复机制，导致胶原蛋白和弹性纤维分解。老化皮肤的外观表现为皮肤粗糙、起皱、色素沉着变化、毛细血管扩张、弹性丧失和紧致度下降，所有这些都会因这些内部和外部因素而加速。多年来，人们一直在研究营养保健品以延缓并对抗这些内部和外部因素，其中许多都存在于天然食用的食物和副产品中。本综述的目的是帮助皮肤科医生了解常见营养保健品的作用机制及其在抗老化和皮肤健康方面可能的功效。
