Urzì Ornella, Gasparro Roberta, Ganji Nima Rabienezhad, Alessandro Riccardo, Raimondo Stefania
Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli Studi di Palermo, 90133 Palermo, Italy.
Membranes (Basel). 2022 Mar 23;12(4):352. doi: 10.3390/membranes12040352.
The release of extracellular vesicles (EVs) is a common language, used by living organisms from different kingdoms as a means of communication between them. Extracellular vesicles are lipoproteic particles that contain many biomolecules, such as proteins, nucleic acids, and lipids. The primary role of EVs is to convey information to the recipient cells, affecting their function. Plant-derived extracellular vesicles (PDEVs) can be isolated from several plant species, and the study of their biological properties is becoming an essential starting point to study cross-kingdom communication, especially between plants and mammalians. Furthermore, the presence of microRNAs (miRNAs) in PDEVs represents an interesting aspect for understanding how PDEVs can target the mammalian genes involved in pathological conditions such as cancer, inflammation, and oxidative stress. In particular, this review focuses on the history of PDEVs, from their discovery, to purification from various matrices, and on the functional role of PDEV-RNAs in cross-kingdom interactions. It is worth noting that miRNAs packaged in PDEVs can be key modulators of human gene expression, representing potential therapeutic agents.
细胞外囊泡（EVs）的释放是一种通用语言，不同界的生物体都将其用作它们之间交流的一种方式。细胞外囊泡是脂蛋白颗粒，包含许多生物分子，如蛋白质、核酸和脂质。细胞外囊泡的主要作用是向受体细胞传递信息，影响其功能。植物来源的细胞外囊泡（PDEVs）可以从多种植物物种中分离出来，对其生物学特性的研究正成为研究跨界交流，尤其是植物与哺乳动物之间跨界交流的重要起点。此外，PDEVs中微小RNA（miRNAs）的存在对于理解PDEVs如何靶向参与癌症、炎症和氧化应激等病理状况的哺乳动物基因来说是一个有趣的方面。特别是，本综述重点关注PDEVs的历史，从其发现到从各种基质中纯化，以及PDEV-RNAs在跨界相互作用中的功能作用。值得注意的是，包装在PDEVs中的miRNAs可能是人类基因表达的关键调节因子，代表着潜在的治疗剂。
