Hijová Emília
Center of Clinical and Preclinical Research (MEDIPARK), Department of Experimental Medicine, Faculty of Medicine, Pavol Jozef Šafárik University, 040 11 Košice, Slovakia.
Metabolites. 2022 Mar 31;12(4):313. doi: 10.3390/metabo12040313.
Obesity and being overweight have reached incredible proportions worldwide and are one of the most common human health problems. The causes of obesity are multifactorial, including a complex interplay among genes, metabolism, diet, physical activity, and the environment. The intestinal microbiota has the ability to affect the host physiology for both benefit and damage, either directly or through microbial metabolites. The aim of this review is to discuss the mechanisms by which the intestinal microbiota could act as a key modifier of obesity and related metabolic abnormalities. The synbiotic components provide an optimal target for modulation of the intestinal microbiota and help reshape the metabolic profile in obese people. The development of novel functional foods containing synbiotic ingredients may present a support in the prevention of obesity as one of the risk factors for chronic diseases. Knowledge of the synbiotic mechanisms of action and the use of new functional foods supplemented with probiotics and prebiotics will facilitate the clinical application and development of individual health care strategies.
肥胖和超重问题在全球范围内已达到惊人的程度，是最常见的人类健康问题之一。肥胖的成因是多方面的，包括基因、新陈代谢、饮食、身体活动和环境之间的复杂相互作用。肠道微生物群有能力直接或通过微生物代谢产物对宿主生理产生有益或有害的影响。本综述的目的是讨论肠道微生物群作为肥胖及相关代谢异常的关键调节因子的作用机制。合生元成分是调节肠道微生物群的最佳靶点，有助于重塑肥胖人群的代谢状况。开发含有合生元成分的新型功能性食品可能有助于预防肥胖这一慢性疾病风险因素。了解合生元的作用机制以及使用添加益生菌和益生元的新型功能性食品将促进临床应用和个体医疗保健策略的发展。
