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在Friend红白血病细胞及其他无c-myc基因重排证据的小鼠细胞类型中，存在起始于第1内含子的c-myc转录本。

Presence of a c-myc transcript initiated in intron 1 in Friend erythroleukemia cells and in other murine cell types with no evidence of c-myc gene rearrangement.

作者信息

Ray D, Meneceur P, Tavitian A, Robert-Lezenes J

出版信息

Mol Cell Biol. 1987 Feb;7(2):940-5. doi: 10.1128/mcb.7.2.940-945.1987.

DOI:10.1128/mcb.7.2.940-945.1987
PMID:3547087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365155/
Abstract

In Friend murine erythroleukemia cells, although no detectable c-myc gene rearrangement was found, we observed, in addition to the normal 2.3-kilobase c-myc transcript, the presence of a 2.3-kilobase c-myc mRNA initiated in intron 1 at a promoter site called P3. The intron 1-initiated transcript has a longer half-life than the normal c-myc mRNA. This c-myc transcript initiated in intron 1 was also found in other murine cell types where no rearrangement of the c-myc locus has been reported.

摘要

在Friend小鼠红白血病细胞中，虽然未发现可检测到的c-myc基因重排，但我们观察到，除了正常的2.3千碱基c-myc转录本外，还存在一种在称为P3的启动子位点处由内含子1起始的2.3千碱基c-myc mRNA。由内含子1起始的转录本的半衰期比正常c-myc mRNA长。在其他尚未报道c-myc基因座重排的小鼠细胞类型中也发现了这种由内含子1起始的c-myc转录本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/1df78406d88c/molcellb00074-0388-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/7e3b62f552de/molcellb00074-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/bf5f1754d587/molcellb00074-0386-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/946e7865d48c/molcellb00074-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/0a13ac60cc2e/molcellb00074-0388-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/1df78406d88c/molcellb00074-0388-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/7e3b62f552de/molcellb00074-0385-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/bf5f1754d587/molcellb00074-0386-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/946e7865d48c/molcellb00074-0387-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/0a13ac60cc2e/molcellb00074-0388-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c34d/365155/1df78406d88c/molcellb00074-0388-b.jpg

相似文献

1
Presence of a c-myc transcript initiated in intron 1 in Friend erythroleukemia cells and in other murine cell types with no evidence of c-myc gene rearrangement.在Friend红白血病细胞及其他无c-myc基因重排证据的小鼠细胞类型中，存在起始于第1内含子的c-myc转录本。
Mol Cell Biol. 1987 Feb;7(2):940-5. doi: 10.1128/mcb.7.2.940-945.1987.
2
Coexistence of a c-myc mRNA initiated in intron 1 with the normal c-myc mRNA and similar regulation of both transcripts in mammalian cells.在哺乳动物细胞中，起始于第1内含子的c-myc mRNA与正常c-myc mRNA共存，且两种转录本具有相似的调控。
Oncogene Res. 1989;5(1):73-8.
3
c-myc antisense transcripts accelerate differentiation and inhibit G1 progression in murine erythroleukemia cells.c-myc反义转录物加速小鼠红白血病细胞的分化并抑制G1期进程。
Mol Cell Biol. 1988 Sep;8(9):3683-95. doi: 10.1128/mcb.8.9.3683-3695.1988.
4
N-myc activation by proviral insertion in MCF 247-induced murine T-cell lymphomas.在MCF 247诱导的小鼠T细胞淋巴瘤中，前病毒插入导致N-myc激活。
Oncogene. 1989 Aug;4(8):1009-14.
5
Continued withdrawal from the cell cycle and regulation of cellular genes in mouse erythroleukemia cells blocked in differentiation by the c-myc oncogene.c-myc癌基因阻断分化的小鼠红白血病细胞中细胞周期的持续退出及细胞基因的调控。
Mol Cell Biol. 1989 Apr;9(4):1714-20. doi: 10.1128/mcb.9.4.1714-1720.1989.
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Expression of c-ras and c-myc oncogenes in murine erythroleukemias induced by Friend viruses.
Leuk Res. 1984;8(6):975-84. doi: 10.1016/0145-2126(84)90051-1.
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Stabilization of myc proto-oncogene proteins during Friend murine erythroleukemia cell differentiation.在Friend小鼠红白血病细胞分化过程中myc原癌基因蛋白的稳定化
J Biol Chem. 1988 Jun 25;263(18):8918-24.
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[Relationship between expression of c-myc and P53 genes and terminal differentiation during induced differentiation in Friend erythroleukemia cells].[Friend红白血病细胞诱导分化过程中c-myc和P53基因表达与终末分化的关系]
Shi Yan Sheng Wu Xue Bao. 1988 Sep;21(3):311-9.
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Multistage Friend erythroleukemia: independent origin of tumor clones with normal or rearranged p53 cellular oncogenes.多阶段Friend红白血病：具有正常或重排的p53细胞癌基因的肿瘤克隆的独立起源。
J Virol. 1987 Sep;61(9):2777-81. doi: 10.1128/JVI.61.9.2777-2781.1987.
10
Erythropoietin activates the receptor in both Rauscher and Friend murine erythroleukemia cells.促红细胞生成素在劳舍尔和弗里德小鼠红白血病细胞中均能激活受体。
J Biol Chem. 1991 Feb 5;266(4):2009-12.

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Front Cell Dev Biol. 2023 Nov 17;11:1270980. doi: 10.3389/fcell.2023.1270980. eCollection 2023.
2
Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).人源和小鼠源II型前胶原（COL2A1）基因中53个内含子的大小以及超过100个用于结合常见转录因子的内含子序列的保守性。
Biochem J. 1995 Jun 15;308 ( Pt 3)(Pt 3):923-9. doi: 10.1042/bj3080923.
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本文引用的文献

1
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas.小鼠c-myc癌基因位于15号染色体上，在浆细胞瘤中易位至12号染色体。
Science. 1982 Dec 24;218(4579):1319-21. doi: 10.1126/science.7146913.
2
The molecular biology of Friend virus.弗瑞德病毒的分子生物学
Biochim Biophys Acta. 1980 Sep 22;605(3):305-24. doi: 10.1016/0304-419x(80)90014-1.
3
Onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient.早幼粒细胞白血病细胞系HL-60及同一患者原代白血病细胞中的癌基因扩增。
mRNA stability in mammalian cells.
哺乳动物细胞中的信使核糖核酸稳定性
Microbiol Rev. 1995 Sep;59(3):423-50. doi: 10.1128/mr.59.3.423-450.1995.
4
Poly(A) shortening and degradation of the 3' A+U-rich sequences of human c-myc mRNA in a cell-free system.在无细胞体系中，人c-myc mRNA的多聚腺苷酸（Poly(A)）缩短及3'端富含A+U序列的降解
Mol Cell Biol. 1988 Apr;8(4):1697-708. doi: 10.1128/mcb.8.4.1697-1708.1988.
5
Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.人类p53癌基因在第1外显子上游有一个启动子，在第1内含子内有第二个更强的启动子。
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5146-50. doi: 10.1073/pnas.85.14.5146.
6
Selective expression of alternative lck mRNAs in human malignant cell lines.人恶性细胞系中替代性lck mRNA的选择性表达。
Mol Cell Biol. 1989 Jul;9(7):2983-8. doi: 10.1128/mcb.9.7.2983-2988.1989.
7
Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase.编码天冬酰胺合成酶的细胞周期基因ts11的组织与表达。
Mol Cell Biol. 1989 Jun;9(6):2350-9. doi: 10.1128/mcb.9.6.2350-2359.1989.
8
An analysis of vertebrate mRNA sequences: intimations of translational control.脊椎动物mRNA序列分析：翻译控制的暗示
J Cell Biol. 1991 Nov;115(4):887-903. doi: 10.1083/jcb.115.4.887.
Nature. 1982 Sep 2;299(5878):61-3. doi: 10.1038/299061a0.
4
Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas.来自小鼠浆细胞瘤中流产性免疫球蛋白基因重排的新型myc癌基因RNA
Cell. 1982 Dec;31(2 Pt 1):443-52. doi: 10.1016/0092-8674(82)90137-4.
5
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.在人类伯基特淋巴瘤和鼠浆细胞瘤细胞中，c-myc基因易位至免疫球蛋白重链基因座。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7837-41. doi: 10.1073/pnas.79.24.7837.
6
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.艾贝尔逊鼠白血病病毒转化的淋巴样细胞系中的多种免疫球蛋白重链基因转录物
Mol Cell Biol. 1982 Apr;2(4):386-400. doi: 10.1128/mcb.2.4.386-400.1982.
7
Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon.人类c-myc基因座的核苷酸序列：第一个外显子内有启发性的开放阅读框。
EMBO J. 1984 Feb;3(2):383-7. doi: 10.1002/j.1460-2075.1984.tb01816.x.
8
Expression of c-ras and c-myc oncogenes in murine erythroleukemias induced by Friend viruses.
Leuk Res. 1984;8(6):975-84. doi: 10.1016/0145-2126(84)90051-1.
9
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.细胞原癌基因myc在鼠浆细胞瘤中通过染色体易位改变至免疫球蛋白基因座，在人类伯基特淋巴瘤中也发生类似重排。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1982-6. doi: 10.1073/pnas.80.7.1982.
10
Expression of cellular oncogenes in human malignancies.细胞癌基因在人类恶性肿瘤中的表达。
Science. 1984 Apr 20;224(4646):256-62. doi: 10.1126/science.6538699.