Al-Mofty Saif El-Din, Karaly Ali H, Sarhan Wessam Awad, Azzazy Hassan M E
Department of Chemistry, School of Sciences and Engineering, The American University in Cairo, New Cairo, Cairo 11835, Egypt.
ACS Omega. 2022 Apr 11;7(15):13210-13220. doi: 10.1021/acsomega.2c00654. eCollection 2022 Apr 19.
The present study describes the development of multifunctional hemostatic sponges to control bleeding. Chitosan (Ch) and poly(vinyl alcohol) (PVA) were selected as the basic polymeric matrix [Ch/PVA] for sponges. Glycerol and citric acid were used as crosslinkers [Ch/PVA/G(Cl)] to enhance the mechanical properties of the developed sponges. Ciprofloxacin (AB) was added to the developed sponge to impart antibacterial activity. Hydroxyapatite (HA) was also added, which would make the sponge suitable for bone surgery. Among the developed sponges, the Ch/PVA/G(Cl)-HA-AB sponge demonstrated enhanced cell viability, mechanical properties, and strong antimicrobial effect against , , and , in addition to platelet aggregation activity. The addition of ciprofloxacin and hydroxyapatite promotes a unique synergistic effect of antimicrobial activity and hemostasis. Thus, the present study introduces Ch/PVA/G(Cl)-HA-AB, a multifunctional hemostatic sponge that would be suitable for bone surgical applications.
本研究描述了用于控制出血的多功能止血海绵的开发。壳聚糖（Ch）和聚乙烯醇（PVA）被选作海绵的基本聚合物基质[Ch/PVA]。甘油和柠檬酸用作交联剂[Ch/PVA/G(Cl)]以增强所开发海绵的机械性能。向所开发的海绵中添加环丙沙星（AB）以赋予抗菌活性。还添加了羟基磷灰石（HA），这将使海绵适用于骨外科手术。在所开发的海绵中，Ch/PVA/G(Cl)-HA-AB海绵除了具有血小板聚集活性外，还表现出增强的细胞活力、机械性能以及对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的强大抗菌效果。环丙沙星和羟基磷灰石的添加促进了抗菌活性和止血的独特协同作用。因此，本研究引入了Ch/PVA/G(Cl)-HA-AB，一种适用于骨外科应用的多功能止血海绵。
