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实用机器学习在疾病诊断中的应用。

Practical machine learning for disease diagnosis.

机构信息

Department of Biomedical Engineering, Swansea University, Swansea, UK.

出版信息

Cell Rep Methods. 2021 Oct 25;1(6):100103. doi: 10.1016/j.crmeth.2021.100103.

DOI:10.1016/j.crmeth.2021.100103
PMID:35474900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9017117/
Abstract

Deep learning neural networks are a powerful tool in the analytical toolbox of modern microscopy, but they come with an exacting requirement for accurately annotated, ground truth cell images. Otesteanu et al. (2021) elegantly streamline this process, implementing network training by using patient-level rather than cell-level disease classification.

摘要

深度学习神经网络是现代显微镜分析工具包中的强大工具,但它们需要准确标注的、真实的细胞图像作为基础。Otesteanu 等人(2021)巧妙地简化了这个过程,通过使用患者级而不是细胞级的疾病分类来实现网络训练。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eb6/9017117/7b9752652ec2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eb6/9017117/7b9752652ec2/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2eb6/9017117/7b9752652ec2/gr1.jpg

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本文引用的文献

1
A weakly supervised deep learning approach for label-free imaging flow-cytometry-based blood diagnostics.基于无标记成像流式细胞术的血液诊断的弱监督深度学习方法。
Cell Rep Methods. 2021 Oct 25;1(6):100094. doi: 10.1016/j.crmeth.2021.100094.
2
Objective assessment of stored blood quality by deep learning.深度学习评估贮存血质量
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21381-21390. doi: 10.1073/pnas.2001227117. Epub 2020 Aug 24.
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Diagnostic Potential of Imaging Flow Cytometry.成像流式细胞术的诊断潜力。
Trends Biotechnol. 2018 Jul;36(7):649-652. doi: 10.1016/j.tibtech.2017.12.008. Epub 2018 Jan 31.
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Data-analysis strategies for image-based cell profiling.基于图像的细胞分析中的数据分析策略。
Nat Methods. 2017 Aug 31;14(9):849-863. doi: 10.1038/nmeth.4397.
5
Imagestream detection and characterisation of circulating tumour cells - A liquid biopsy for hepatocellular carcinoma?基于液基活检的循环肿瘤细胞的影像检测与特征分析——对肝细胞癌有何影响?
J Hepatol. 2016 Aug;65(2):305-13. doi: 10.1016/j.jhep.2016.04.014. Epub 2016 Apr 27.
6
Label-free cell cycle analysis for high-throughput imaging flow cytometry.用于高通量成像流式细胞术的无标记细胞周期分析
Nat Commun. 2016 Jan 7;7:10256. doi: 10.1038/ncomms10256.
7
Machine learning in cell biology - teaching computers to recognize phenotypes.细胞生物学中的机器学习——教计算机识别细胞表型
J Cell Sci. 2013 Dec 15;126(Pt 24):5529-39. doi: 10.1242/jcs.123604. Epub 2013 Nov 20.
8
Introduction to the quantitative analysis of two-dimensional fluorescence microscopy images for cell-based screening.用于基于细胞筛选的二维荧光显微镜图像定量分析简介
PLoS Comput Biol. 2009 Dec;5(12):e1000603. doi: 10.1371/journal.pcbi.1000603. Epub 2009 Dec 24.