College of Food Science, Southwest University, Beibei, Chongqing 400715, China.
Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine Chongqing Medical University, Chongqing 400016, China.
J Agric Food Chem. 2022 May 11;70(18):5610-5623. doi: 10.1021/acs.jafc.2c01883. Epub 2022 Apr 27.
Pu-erh tea is a healthy beverage rich in phytochemicals, and its effect on the risk of inducing circadian rhythm disorders (CRD) is unclear. In this study, healthy mice were given water or 0.25% (w/v) Pu-erh tea for 7 weeks, followed by a 40 day disruption of the light/dark cycle. CRD caused dysregulation of neurotransmitter secretion and clock gene oscillations, intestinal inflammation, and disruption of intestinal microbes and metabolites. Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Furthermore, its metabolites (e.g., IAA, Indole, 5-HT) enhanced hepatic glycolipid metabolism and down-regulated intestinal oxidative stress by improving the brain hormone release. Tryptophan metabolites and bile acids also promoted liver lipid metabolism and inhibited intestinal inflammation (MyD88/NF-κB) via the enterohepatic circulation. Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis.
普洱茶是一种富含植物化学物质的健康饮品，其对诱发昼夜节律紊乱（CRD）风险的影响尚不清楚。在这项研究中，健康小鼠给予水或 0.25%（w/v）普洱茶 7 周，随后进行 40 天的明暗循环中断。CRD 导致神经递质分泌和时钟基因振荡、肠道炎症以及肠道微生物和代谢物紊乱失调。普洱茶通过肠-肝-脑轴增强了色氨酸代谢的吲哚和 5-羟色胺途径。此外，其代谢物（例如 IAA、吲哚、5-HT）通过改善脑激素释放，增强了肝糖脂代谢，下调了肠道氧化应激。色氨酸代谢物和胆汁酸也通过肠肝循环促进肝脏脂质代谢，抑制肠道炎症（MyD88/NF-κB）。总之，0.25%（w/v）普洱茶通过促进色氨酸代谢的吲哚和 5-HT 途径以及肠-肝-脑轴中的信号相互作用，具有预防 CRD 的潜力。
