Verboschi Francesca, Domanico Daniela, Nebbioso Marcella, Corradetti Giulia, Zaccaria Scalinci Sergio, Vingolo Enzo Maria
Funct Neurol. 2013 Oct-Dec;28(4):285-91.
The aim of this study was to evaluate the efficacy of visual rehabilitation with MP-1 microperimeter biofeedback in advanced optic neural dysfunction due to glaucoma, and to precisely characterize fixation stability and location in affected patients. Ten patients (18 eyes) with advanced glaucoma were submitted to a rehabilitation protocol that consisted of: a 25-item questionnaire (National Eye Institute Visual Functioning Que stionnaire); measurement of visual acuity; a reading speed test; microperimetry with fixation study, retinal sensitivity and the bivariate contour ellipse area (BCEA). The rehabilitation program consisted of 10 training sessions of 10 minutes per eye performed over a period of one week and was repeated at four months, eight months, and one year. Statistical analysis was performed using the Student's t-test and Spearman correlation; p values less than 0.05 were considered statistically significant. In 13 eyes fixation changed from unstable to relatively unstable while its location changed from predominantly eccentric to predominantly central. In five eyes, fixation changed from relatively unstable to stable with a change of location from poor central fixation to predominantly New trends in visual rehabilitation with MP-1 microperimeter biofeedback: optic neural dysfunction central fixation. Mean retinal sensitivity changed from 7.43±8.28 dB to 8.33±9.04 dB (p<0.05); the mean best corrected visual acuity was 0.98±0.66 logMAR at the baseline assessment, and 0.75±0.6 logMAR at the end of rehabilitation (p>0.05); reading speed improved from a mean value of 31.4±4.3 words/minute to 55.6±3.2 words/minute at the end of the training (p<0.05). The BCEA changed from 0.94±0.39 deg2 to 0.86±0.46 deg2 (p=0.76). Rehabilitation with MP-1 biofeedback in patients with advanced glaucoma is a useful means of improving these patients' fixation stability, reading speed and quality of life.
本研究旨在评估MP - 1微视野生物反馈视觉康复对青光眼所致晚期视神经功能障碍的疗效，并精确描述患眼的注视稳定性和注视位置。10例（18只眼）晚期青光眼患者接受了一项康复方案，该方案包括：一份25项问卷（美国国立眼科研究所视觉功能问卷）；视力测量；阅读速度测试；带有注视研究、视网膜敏感度和双变量轮廓椭圆面积（BCEA）的微视野检查。康复计划包括每只眼进行10次每次10分钟的训练，为期一周，在4个月、8个月和1年时重复进行。采用学生t检验和Spearman相关性进行统计分析；p值小于0.05被认为具有统计学意义。13只眼中，注视从不稳定变为相对稳定，而其位置从主要偏心变为主要中心。5只眼中，注视从相对不稳定变为稳定，位置从较差的中心注视变为主要中心注视。平均视网膜敏感度从7.43±8.28 dB变为8.33±9.04 dB（p<0.05）；基线评估时平均最佳矫正视力为0.98±0.66 logMAR，康复结束时为0.75±0.6 logMAR（p>0.05）；训练结束时阅读速度从平均值31.4±4.3字/分钟提高到55.6±3.2字/分钟（p<0.05）。BCEA从0.94±0.39度²变为0.86±0.46度²（p = 0.76）。对晚期青光眼患者采用MP - 1生物反馈进行康复是提高这些患者注视稳定性、阅读速度和生活质量的有效方法。
