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mA 阅读器 YTHDC1 在生物过程和疾病中的作用及机制。

Roles and mechanisms of the mA reader YTHDC1 in biological processes and diseases.

作者信息

Yan Huaqing, Zhang Liqi, Cui Xiaobo, Zheng Sinian, Li Rubing

机构信息

Department of Urology, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, 315000, PR China.

Department of Reproductive Medicine, Ningbo First Hospital, Ningbo, Zhejiang, 315000, PR China.

出版信息

Cell Death Discov. 2022 May 2;8(1):237. doi: 10.1038/s41420-022-01040-2.

DOI:10.1038/s41420-022-01040-2
PMID:35501308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061745/
Abstract

N6-methyladenosine (mA) is a key area in Epigenetics and has been increasingly focused these years. In the mA process, readers recognize the mA modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important mA reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy.

摘要

N6-甲基腺苷（mA）是表观遗传学中的一个关键领域，近年来受到越来越多的关注。在mA过程中，阅读蛋白识别mRNA或非编码RNA上的mA修饰并介导不同的下游事件。新兴研究表明，重要的mA阅读蛋白YTHDC1在许多生物学功能和疾病进展，尤其是癌症中发挥关键作用。在此，我们总结了YTHDC1在生物学功能和疾病中的当前机制，并为未来研究提供指导，以提供临床诊断和治疗的潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/a138644382ee/41420_2022_1040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/9bde5ad9b057/41420_2022_1040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/d20a843c0e4b/41420_2022_1040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/a138644382ee/41420_2022_1040_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/9bde5ad9b057/41420_2022_1040_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/d20a843c0e4b/41420_2022_1040_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c53f/9061745/a138644382ee/41420_2022_1040_Fig3_HTML.jpg

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