Roles and mechanisms of the mA reader YTHDC1 in biological processes and diseases.

N6-methyladenosine (mA) is a key area in Epigenetics and has been increasingly focused these years. In the mA process, readers recognize the mA modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important mA reader, plays a key role in many biological functions and disease progression, especially cancers. Here we summarized the current mechanisms of YTHDC1 in biological functions and diseases and offered guidance for future researches to provide potential strategy for clinical diagnose and therapy.