Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Institute of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang, China.
BMC Neurosci. 2022 May 2;23(1):26. doi: 10.1186/s12868-022-00709-9.
Transcranial magneto-acoustical stimulation (TMAS) is a noninvasive technique that has advantages in spatial resolution and penetration depth. It changes the firing properties of neurons through the current generated by focused ultrasound and a static magnetic field. Spike-frequency adaptation is an important dynamic characteristic of neural information processing.
To address the effects of TMAS on neural spike-frequency adaptation, this study employs some ultrasound and magnetic field parameters, such as magnetic flux density, ultrasonic intensity, fundamental ultrasonic frequency, modulation frequency, and duty cycle. Using these different ultrasound and magnetic field parameters, membrane potential curves, spike-frequency curves, and adapted onset spike-frequency curves are exhibited and analyzed.
The results show that spike-frequency adaptation is strongly dependent on ultrasonic intensity and magnetic flux density and is rarely affected by other parameters. However, modulation frequency and duty cycle influence membrane potentials and spike frequencies to some degree.
This study reveals the mechanism of the effects of TMAS on neural spike-frequency adaptation and serves as theoretical guidance for TMAS experiments.
经颅磁声刺激（TMAS）是一种具有空间分辨率和穿透深度优势的非侵入性技术。它通过聚焦超声和静磁场产生的电流来改变神经元的放电特性。尖峰频率适应是神经信息处理的一个重要动态特性。
为了研究 TMAS 对神经尖峰频率适应的影响，本研究采用了一些超声和磁场参数，如磁通密度、超声强度、基频、调制频率和占空比。利用这些不同的超声和磁场参数，展示和分析了膜电位曲线、尖峰频率曲线和适应起始尖峰频率曲线。
结果表明，尖峰频率适应强烈依赖于超声强度和磁通密度，而很少受其他参数的影响。然而，调制频率和占空比在一定程度上影响膜电位和尖峰频率。
本研究揭示了 TMAS 对神经尖峰频率适应影响的机制，为 TMAS 实验提供了理论指导。
