Department of Immunology, Tumor Immunology Group, Leiden University Medical Center, Leiden, The Netherlands.
Methods Mol Biol. 2022;2451:597-604. doi: 10.1007/978-1-0716-2099-1_31.
Tumor ablation by photodynamic therapy (PDT) results in a strong reduction in tumor mass and can lead to improved recognition of tumor cells by the immune system. This supports combinations of PDT and immunotherapy for the treatment of advanced tumors. Therapeutic vaccination is a tumor-specific type of cancer immunotherapy that aims to directly strengthen the immune response against tumor antigens. In this chapter, we describe the combination of PDT and therapeutic vaccination using a peptide tumor antigen vaccine.
光动力疗法（PDT）消融肿瘤可导致肿瘤质量的强烈减少，并可改善免疫系统对肿瘤细胞的识别。这支持 PDT 与免疫疗法联合用于治疗晚期肿瘤。治疗性疫苗接种是一种针对肿瘤的癌症免疫疗法，旨在直接增强针对肿瘤抗原的免疫反应。在本章中，我们描述了使用肽肿瘤抗原疫苗的 PDT 和治疗性疫苗接种的联合应用。
