Pang Yu, Li Yuxing, Wang Xuefeng, Qi Chenjie, Yang Yi, Ren Tian-Ling
Institute of Microelectronics, Tsinghua University 100084 Beijing China
Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University 100084 Beijing China.
RSC Adv. 2019 Feb 11;9(9):5076-5082. doi: 10.1039/c8ra10257k. eCollection 2019 Feb 5.
Intraocular pressure (IOP) is the key indicator to assess the risk for and status of glaucoma patients, and medication at high IOP values slows down exacerbation of glaucoma. However, the IOP value is subject to circadian variation and cannot be measured continuously in clinical practice. Herein, we have fabricated a contact lens with a Wheatstone bridge circuit for non-invasive monitoring of IOP. A metal electrode has been used as a strain gauge to measure the weak deformation of the eyeball caused by IOP variation. Tests on a model eye indicate that the contact lens exhibits a high sensitivity of 20 μV mmHg and excellent dynamic cycling performance at different speeds of IOP variation. These results demonstrate that the contact lens sensor is promising for continuous IOP monitoring of glaucoma disease, regardless of the posture and activities of the patient.
眼压（IOP）是评估青光眼患者风险和病情的关键指标，高眼压时用药可减缓青光眼的恶化。然而，眼压值存在昼夜变化，在临床实践中无法进行连续测量。在此，我们制作了一种带有惠斯通电桥电路的隐形眼镜，用于眼压的无创监测。金属电极被用作应变计，以测量眼压变化引起的眼球微弱变形。在模型眼上的测试表明，该隐形眼镜具有20 μV/mmHg的高灵敏度，并且在不同眼压变化速度下具有出色的动态循环性能。这些结果表明，无论患者的姿势和活动如何，该隐形眼镜传感器在青光眼疾病的眼压连续监测方面具有广阔前景。
