Department of Ophthalmology, Jinan People's Hospital Shandong, Jinan 271100, China.
J Healthc Eng. 2022 Mar 28;2022:2271937. doi: 10.1155/2022/2271937. eCollection 2022.
Glaucoma is caused by excessive aqueous humor in the eye, resulting in a continuous or intermittent increase of intraocular pressure, which exceeds the tolerance of the eyeball and damages the optic nerve. Existing treatments for glaucoma do not work well or have significant side effects. Intraocular pressure signal is a very important physiological signal that needs real-time and accurate monitoring in glaucoma patients, especially in severe glaucoma patients. Therefore, long-term, real-time, and accurate monitoring of intraocular pressure is of great significance for the diagnosis and treatment of glaucoma patients. The use of wearable devices for real-time ocular diagnosis and treatment of glaucoma patients is an effective approach. However, the current commonly used intraocular pressure measurement and monitoring technology is difficult to meet the diagnosis and monitoring needs of glaucoma patients in terms of size, measurement accuracy, power consumption, and intelligence. Therefore, facing the needs of glaucoma disease treatment, this topic studies an implantable flexible intraocular pressure sensor for long-term continuous monitoring of intraocular pressure in glaucoma patients and mainly focuses on the working principle, structural design, process fabrication, measurement and control system, characterization, and performance test of the intraocular pressure sensor. It is of great significance for personalized and accurate treatment of glaucoma patients.
青光眼是由于眼内房水过多，导致眼内压持续或间歇升高，超过眼球耐受，损害视神经所致。现有的青光眼治疗方法效果不佳或有明显的副作用。眼压信号是青光眼患者非常重要的生理信号，需要实时、准确地监测，尤其是在重度青光眼患者中。因此，长期、实时、准确地监测眼压对青光眼患者的诊断和治疗具有重要意义。可穿戴设备用于实时眼部诊断和治疗青光眼患者是一种有效的方法。然而，目前常用的眼压测量和监测技术在尺寸、测量精度、功耗和智能化方面很难满足青光眼患者的诊断和监测需求。因此，针对青光眼疾病治疗的需求，本课题研究了一种用于青光眼患者长期连续眼压监测的植入式柔性眼压传感器，主要研究眼压传感器的工作原理、结构设计、工艺制作、测量控制系统、特性分析和性能测试。这对于青光眼患者的个性化和精确治疗具有重要意义。
