Xie Lu, Yang Yuanyi, Fu Zhiqiang, Li Yunfei, Shi Jiacheng, Ma Daichuan, Liu Suilin, Luo Daibing
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontic, West China Hospital of Stomatology, Sichuan University Chengdu 610041 China.
Department of Materials Engineering, Sichuan College of Architectural Technology Deyang 618000 China.
RSC Adv. 2019 Jan 7;9(2):781-789. doi: 10.1039/c8ra08453j. eCollection 2019 Jan 2.
Bone repairing materials play an essential role in the repair treatment of bone defects. The presence of calcium phosphate invertebrates is of significance for bone repairing processes. However, the mechanical properties and osteogenic activities of many current calcium phosphate materials are not ideal, which limit their biological applications. Therefore, it is an effective alternative strategy to study the modification of calcium phosphate biomaterials to address these limitations. In this research, in order to enhance the biological performance of tricalcium phosphate (β-TCP), metal species (Fe and Zn) modified β-TCP materials through the co-precipitation method were successfully developed. The physical, chemical and biological properties of the binary composites were carefully studied for the first time. The bioactivities of the Fe-TCP and Zn-TCP were evaluated by simulating body fluid (SBF) immersion experiments, blood compatibility, and cytotoxicity tests. The findings demonstrated that the metal-TCP with excellent cytocompatibility and osteogenic properties shows good potential in medical applications.
骨修复材料在骨缺损的修复治疗中起着至关重要的作用。磷酸钙无脊椎动物的存在对骨修复过程具有重要意义。然而，目前许多磷酸钙材料的力学性能和成骨活性并不理想，这限制了它们的生物学应用。因此，研究磷酸钙生物材料的改性以解决这些局限性是一种有效的替代策略。在本研究中，为了提高磷酸三钙（β-TCP）的生物学性能，通过共沉淀法成功制备了金属物种（Fe和Zn）改性的β-TCP材料。首次对二元复合材料的物理、化学和生物学性质进行了仔细研究。通过模拟体液（SBF）浸泡实验、血液相容性和细胞毒性测试对Fe-TCP和Zn-TCP的生物活性进行了评估。研究结果表明，具有优异细胞相容性和成骨性能的金属-TCP在医学应用中具有良好的潜力。
