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分生孢子在妇科癌细胞中具有抗增殖和诱导凋亡的特性。

conidia possess antiproliferative and inducing apoptosis properties in gynaecological carcinoma cells.

作者信息

Sun Yan-Fang, Sun Yang, Wang Zhi-An, Han Rui-Lian, Lu Hong-Fei, Zhang Jia-Lei, Liu Hong-Tao, Wang Shi-Xian, Wang Pan, Dian Lu-Lu, Liang Zong-Suo

机构信息

Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang Province, College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China.

College of Resource and Civil Engineering, Northeastern University, Shenyang, China.

出版信息

Mycology. 2017 Oct 11;8(4):327-334. doi: 10.1080/21501203.2017.1386243. eCollection 2017.

DOI:10.1080/21501203.2017.1386243
PMID:30123653
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6059127/
Abstract

is an entomogenous fungus that has been used as a traditional Chinese medicinal materials to treat different diseases, including cancer. However, conidia for inhibitory activity against breast cancer cells growth are still not systematically studied. The present aim was to elucidate the phytochemical composition of conidia and to explore relevant anti-cancer potential in gynaecological carcinoma MCF-7 and Hela cells. conidia were identified by UPLC-ESI-Q-TOF-MS: high performance liquid chromatography-electrospray/quadrupole time of flight tandem mass spectrometry technology. Eight main compounds were identified which are nucleosides, cordycepic acid, cordycepin, beauvericin and myriocin by MS fragmentation ions. The nuclear morphology indicated the typical characteristics of apoptosis by Hoechst staining. Annexin V/PI staining revealed that the number of apoptotic cells was increased by conidia treatment. Furthermore, conidia also induced the caspase-mediated mitochondrial apoptosis pathway. The findings suggest that the full-scale active ingredients highlight the significance of conidia as potential anti-cancer agent in China.

摘要

是一种虫生真菌，已被用作治疗包括癌症在内的各种疾病的传统中药材。然而，其分生孢子对乳腺癌细胞生长的抑制活性仍未得到系统研究。目前的目的是阐明分生孢子的植物化学成分，并探索其在妇科癌MCF-7和Hela细胞中的相关抗癌潜力。通过超高效液相色谱-电喷雾/四极杆飞行时间串联质谱技术（UPLC-ESI-Q-TOF-MS）对分生孢子进行鉴定。通过质谱裂解离子鉴定出8种主要化合物，分别为核苷、虫草酸、虫草素、白僵菌素和麦角硫因。通过Hoechst染色，细胞核形态显示出典型的凋亡特征。膜联蛋白V/碘化丙啶染色显示，分生孢子处理后凋亡细胞数量增加。此外，分生孢子还诱导了半胱天冬酶介导的线粒体凋亡途径。研究结果表明，这些全面的活性成分凸显了分生孢子作为中国潜在抗癌药物的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/b7b3e277dcea/TMYC_A_1386243_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/3ae89aed7176/TMYC_A_1386243_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/22473e4bd427/TMYC_A_1386243_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/d676d3c87ab5/TMYC_A_1386243_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/b7b3e277dcea/TMYC_A_1386243_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/3ae89aed7176/TMYC_A_1386243_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/22473e4bd427/TMYC_A_1386243_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/d676d3c87ab5/TMYC_A_1386243_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48cb/6059127/b7b3e277dcea/TMYC_A_1386243_F0004_OC.jpg

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