College of Biomedical Engineering, School of Chemical Engineering, Sichuan University, Chengdu, 610065, China.
State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Adv Healthc Mater. 2022 Jul;11(14):e2200641. doi: 10.1002/adhm.202200641. Epub 2022 May 24.
Clinically, bacteria-induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting of simvastatin (SIM)-laden metal-organic frameworks and polydopamine nanolayers is created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multimodal osteogenicity mechanisms of zinc ion (Zn ) therapy, SIM drug therapy, and surface micro-/nano-topological stimulation. Under the illumination of near-infrared (NIR) light, singlet oxygen ( O ) and local hyperthermia are produced; besides, NIR light dramatically accelerates the release of Zn ions from heterostructured coatings. Gram-positive and -negative bacteria are effectively eradicated by the synergy of photothermal/photodynamic effects and photo-induced accelerated delivery of Zn ions. The superior osteogenicity and osseointegration, as well as photoswitchable disinfection controlled by NIR light are corroborated via in vivo results. This work highlights the great potential of photoresponsive heterostructured orthopedic implants in treatment of the noninvasive bone reconstruction of bacteria-associated infectious tissues through multimodal phototherapy and photoswitchable ion-therapy.
临床上，细菌诱导的感染和不足的骨整合特性不可避免地导致骨科植入物的失败。在此，在多孔生物惰性聚醚醚酮植入物上构建了由载有辛伐他汀（SIM）的金属有机骨架和聚多巴胺纳米层组成的异质结构涂层。通过锌离子（Zn ）治疗、SIM 药物治疗和表面微/纳米拓扑刺激的多种成骨机制，异质结构涂层显著促进了细胞相容性和成骨分化。在近红外（NIR）光的照射下，会产生单线态氧（ O ）和局部热疗；此外，NIR 光还能显著加速异质结构涂层中 Zn 离子的释放。光热/光动力效应和光诱导加速 Zn 离子释放的协同作用有效地消灭了革兰氏阳性菌和革兰氏阴性菌。通过体内实验证实了 NIR 光控制的光响应性异质结构骨科植入物在通过多模式光疗和光切换离子疗治疗与细菌相关的感染组织的非侵入性骨重建方面具有巨大潜力。
