原位肝移植后α1-抗胰蛋白酶表型的变化。
Change in alpha 1-antitrypsin phenotype after orthotopic liver transplant.
作者信息
van Furth R, Kramps J A, van der Putten A B, Krom R A, Gips C H
出版信息
Clin Exp Immunol. 1986 Dec;66(3):669-72.
Abstract
The aim of the present study was to determine the interval after orthotopic liver transplant during which the alpha 1-AT phenotype in the serum changes. Eleven patients could be evaluated because the donor and recipient had different alpha 1-AT phenotypes. The results showed that within 1 to 3 days of the transplant donor alpha 1-AT is already present in the serum of the recipient, and subsequently the transplanted liver continued to synthesize alpha 1-AT of the donor phenotype. The result confirmed that liver parenchymal cells are the main site of alpha 1-AT synthesis.
摘要
本研究的目的是确定原位肝移植后血清中α1-抗胰蛋白酶（alpha 1-AT）表型发生变化的时间间隔。由于供体和受体具有不同的α1-抗胰蛋白酶表型，因此可以对11名患者进行评估。结果显示，移植后1至3天内，受体血清中已出现供体α1-抗胰蛋白酶，随后移植肝脏继续合成供体表型的α1-抗胰蛋白酶。该结果证实肝实质细胞是α1-抗胰蛋白酶合成的主要部位。
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本文引用的文献
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Synthesis of alpha 1-anti-trypsin by human monocytes.人单核细胞合成α1-抗胰蛋白酶。
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Orthotopic liver transplantation in Groningen, The Netherlands (1979-1983).荷兰格罗宁根的原位肝移植（1979 - 1983年）。
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