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Optocapacitance: physical basis and its application.

作者信息

Pinto Bernardo I, Bassetto Carlos A Z, Bezanilla Francisco

机构信息

Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637 USA.

Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

出版信息

Biophys Rev. 2022 Apr 13;14(2):569-577. doi: 10.1007/s12551-022-00943-9. eCollection 2022 Apr.

DOI:10.1007/s12551-022-00943-9
PMID:35528029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9042976/
Abstract

The observation that membrane capacitance increases with temperature has led to the development of new methods of neuronal stimulation using light. The optocapacitive effect refers to a light-induced change in capacitance produced by the heating of the membrane through a photothermal effect. This change in capacitance manifests as a current, named optocapacitive current that depolarizes cells and therefore can be used to stimulate excitable tissues. Here, we discuss how optocapacitance arises from basic membrane properties, the characteristics of the optocapacitive current, its use for neuronal stimulation, and the challenges for its application in vivo.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/7f027412ab52/12551_2022_943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/0ea0fa09977b/12551_2022_943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/8ed8aeb978d0/12551_2022_943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/7f027412ab52/12551_2022_943_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/0ea0fa09977b/12551_2022_943_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/8ed8aeb978d0/12551_2022_943_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a17/9043173/7f027412ab52/12551_2022_943_Fig3_HTML.jpg

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[10]
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本文引用的文献

[1]
Nanoparticles for Targeted Brain Drug Delivery: What Do We Know?

Int J Mol Sci. 2021-10-28

[2]
Shedding Light on Thermally Induced Optocapacitance at the Organic Biointerface.

J Phys Chem B. 2021-9-30

[3]
TiCT MXene Flakes for Optical Control of Neuronal Electrical Activity.

ACS Nano. 2021-9-28

[4]
Structural and functional consequences of reversible lipid asymmetry in living membranes.

Nat Chem Biol. 2020-12

[5]
Challenges for Therapeutic Applications of Opsin-Based Optogenetic Tools in Humans.

Front Neural Circuits. 2020

[6]
Remote nongenetic optical modulation of neuronal activity using fuzzy graphene.

Proc Natl Acad Sci U S A. 2020-6-1

[7]
Lipidomic atlas of mammalian cell membranes reveals hierarchical variation induced by culture conditions, subcellular membranes, and cell lineages.

Soft Matter. 2021-1-22

[8]
Wireless, battery-free, fully implantable multimodal and multisite pacemakers for applications in small animal models.

Nat Commun. 2019-12-17

[9]
Thermal constraints on in vivo optogenetic manipulations.

Nat Neurosci. 2019-6-17

[10]
Rational design of silicon structures for optically controlled multiscale biointerfaces.

Nat Biomed Eng. 2018-7

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