• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

菊粉及其组合对1,2 - 二甲基肼诱导的小鼠结肠癌中JNK - 1/β - 连环蛋白信号通路的调节作用

Modulation of JNK-1/ β-catenin signaling by , inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice.

作者信息

Ali Mohammed S, Hussein Rasha M, Gaber Yasser, Hammam Olfat A, Kandeil Mohamed A

机构信息

Department of Biochemistry, Faculty of Pharmacy, Beni-Suef University Salah Salem Street 62514 Beni-Suef Egypt

Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Mutah University 61710 Al-Karak Jordan.

出版信息

RSC Adv. 2019 Sep 17;9(50):29368-29383. doi: 10.1039/c9ra04388h. eCollection 2019 Sep 13.

DOI:10.1039/c9ra04388h
PMID:35528422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9071812/
Abstract

Colon cancer is a complex disease that involves numerous genetic alterations that change the normal colonic mucosa into invasive adenocarcinoma. In the current study, the protective effects of inulin (prebiotic), (, probiotic) and their combination (synbiotic) on 1,2-dimethylhydrazine (DMH)-induced colon cancer in male Swiss mice were evaluated. Animals were divided into: Control group, DMH-treated group, DMH plus inulin, DMH plus and DMH plus inulin plus -treated groups. Fecal microbiome analysis, biochemical measurements, histopathological examination of the colon tissues, immunostaining and Western blotting analysis of β-catenin, GSK3β and JNK-1 were performed. The prebiotic-, probiotic- and synbiotic-treated groups showed decreased levels of carcinoembryonic antigen and a lower number of aberrant crypt foci compared to the DMH-treated group with the synbiotic group exhibiting a superior effect. Furthermore, all treatments showed a body weight-reducing effect. Administration of inulin, or their combination increased the expression level of phospho-JNK-1 while they decreased the expression level of β-catenin and phospho-GSK3β. Remarkably, treatment resulted in enrichment of certain beneficial bacterial genera and . Therefore, administration of and inulin as a synbiotic combination protects against colon cancer in mice.

摘要

结肠癌是一种复杂的疾病，涉及众多基因改变，这些改变将正常结肠黏膜转变为浸润性腺癌。在本研究中，评估了菊粉（益生元）、（益生菌）及其组合（合生元）对1,2 - 二甲基肼（DMH）诱导的雄性瑞士小鼠结肠癌的保护作用。动物被分为：对照组、DMH处理组、DMH加菊粉组、DMH加组和DMH加菊粉加处理组。进行了粪便微生物组分析、生化测量、结肠组织的组织病理学检查、β - 连环蛋白、糖原合成酶激酶3β（GSK3β）和应激活化蛋白激酶1（JNK - 1）的免疫染色及蛋白质印迹分析。与DMH处理组相比，益生元、益生菌和合生元处理组的癌胚抗原水平降低，异常隐窝病灶数量减少，其中合生元组效果更佳。此外，所有处理均显示出体重减轻的作用。给予菊粉、或其组合可增加磷酸化JNK - 1的表达水平，同时降低β - 连环蛋白和磷酸化GSK3β的表达水平。值得注意的是，处理导致某些有益细菌属和的富集。因此，给予和菊粉作为合生元组合可预防小鼠结肠癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/3b35bd32ac23/c9ra04388h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/933f2ee1d461/c9ra04388h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/dd9bf90ffdda/c9ra04388h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/dec400131f6d/c9ra04388h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/5f05d3e02073/c9ra04388h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/c67c38717145/c9ra04388h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/e8033fa098dd/c9ra04388h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/f2a1c2b19b43/c9ra04388h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/3b35bd32ac23/c9ra04388h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/933f2ee1d461/c9ra04388h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/dd9bf90ffdda/c9ra04388h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/dec400131f6d/c9ra04388h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/5f05d3e02073/c9ra04388h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/c67c38717145/c9ra04388h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/e8033fa098dd/c9ra04388h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/f2a1c2b19b43/c9ra04388h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3953/9071812/3b35bd32ac23/c9ra04388h-f8.jpg

相似文献

1
Modulation of JNK-1/ β-catenin signaling by , inulin and their combination in 1,2-dimethylhydrazine-induced colon cancer in mice.菊粉及其组合对1,2 - 二甲基肼诱导的小鼠结肠癌中JNK - 1/β - 连环蛋白信号通路的调节作用
RSC Adv. 2019 Sep 17;9(50):29368-29383. doi: 10.1039/c9ra04388h. eCollection 2019 Sep 13.
2
Synbiotic (Lactobacillus rhamnosus+Lactobacillus acidophilus+inulin) attenuates oxidative stress and colonic damage in 1,2 dimethylhydrazine dihydrochloride-induced colon carcinogenesis in Sprague-Dawley rats: a long-term study.合生元（鼠李糖乳杆菌+嗜酸乳杆菌+菊粉）减轻1,2-二甲基肼二盐酸盐诱导的Sprague-Dawley大鼠结肠癌发生中的氧化应激和结肠损伤：一项长期研究。
Eur J Cancer Prev. 2014 Nov;23(6):550-9. doi: 10.1097/CEJ.0000000000000054.
3
Protective Effect of Lactobacillus casei on DMH-Induced Colon Carcinogenesis in Mice.干酪乳杆菌对 DMH 诱导的小鼠结肠癌发生的保护作用。
Probiotics Antimicrob Proteins. 2017 Jun;9(2):163-171. doi: 10.1007/s12602-017-9253-2.
4
Co-administration of a probiotic strain Lactobacillus plantarum LS/07 CCM7766 with prebiotic inulin alleviates the intestinal inflammation in rats exposed to N,N-dimethylhydrazine.益生菌植物乳杆菌LS/07 CCM7766与益生元菊粉共同给药可减轻暴露于N，N-二甲基肼的大鼠的肠道炎症。
Int Immunopharmacol. 2015 Feb;24(2):361-368. doi: 10.1016/j.intimp.2014.12.022. Epub 2014 Dec 20.
5
Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates the formation of aberrant crypt foci, mucin-depleted foci, and cell proliferation on 1,2-dimethylhydrazine-induced colorectal carcinogenesis in Wistar rats.含有嗜酸乳杆菌和双歧双歧杆菌的益生菌达希可调节1,2 - 二甲基肼诱导的Wistar大鼠结直肠癌发生过程中异常隐窝病灶、黏蛋白缺失病灶的形成以及细胞增殖。
Rejuvenation Res. 2014 Aug;17(4):325-33. doi: 10.1089/rej.2013.1537.
6
Yacon (Smallanthus sonchifolius) and Lactobacillus acidophilus CRL 1014 reduce the early phases of colon carcinogenesis in male Wistar rats.雪莲果（小葵子）和嗜酸乳杆菌CRL 1014可降低雄性Wistar大鼠结肠癌发生的早期阶段。
Food Res Int. 2015 Aug;74:48-54. doi: 10.1016/j.foodres.2015.04.034. Epub 2015 Apr 24.
7
Immunomodulatory Effect of Lactobacillus casei in a Murine Model of Colon Carcinogenesis.鼠结直肠癌模型中干酪乳杆菌的免疫调节作用。
Probiotics Antimicrob Proteins. 2020 Sep;12(3):1012-1024. doi: 10.1007/s12602-019-09611-z.
8
Bone Marrow Cell Therapy on 1,2-Dimethylhydrazine (DMH)-Induced Colon Cancer in Rats.骨髓细胞疗法对1,2-二甲基肼（DMH）诱导的大鼠结肠癌的作用
Cell Physiol Biochem. 2018;45(3):1072-1083. doi: 10.1159/000487349. Epub 2018 Feb 7.
9
Lactobacillus casei BL23 regulates Treg and Th17 T-cell populations and reduces DMH-associated colorectal cancer.干酪乳杆菌BL23调节调节性T细胞和辅助性T细胞17亚群，并减少二甲基肼相关的结直肠癌。
J Gastroenterol. 2016 Sep;51(9):862-73. doi: 10.1007/s00535-015-1158-9. Epub 2016 Jan 9.
10
The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats.益生菌微生物和生物活性化合物对化学诱导大鼠致癌作用的影响。
Neoplasma. 2010;57(5):422-8. doi: 10.4149/neo_2010_05_422.

引用本文的文献

1
Harnessing the Power of Microbiota: How Do Key Species Aid in Clearing High-Risk Human Papilloma Virus Infection and Promoting the Regression of Cervical Dysplasia?利用微生物群的力量：关键物种如何帮助清除高危型人乳头瘤病毒感染并促进宫颈发育异常的消退？
Biology (Basel). 2025 Aug 19;14(8):1081. doi: 10.3390/biology14081081.
2
Molecular Mechanisms of Probiotic Action Against Gastrointestinal Cancers.益生菌抗胃肠道癌症作用的分子机制
Int J Mol Sci. 2025 Aug 14;26(16):7857. doi: 10.3390/ijms26167857.
3
inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation.

本文引用的文献

1
Pizotifen Inhibits the Proliferation and Migration of Colon Cancer HCT116 Cells by Down-regulating Wnt Signaling Pathway.苯噻啶通过下调Wnt信号通路抑制结肠癌HCT116细胞的增殖和迁移。
Ann Clin Lab Sci. 2019 Mar;49(2):183-188.
2
Chemopreventive effect of Callistemon citrinus (Curtis) Skeels against colon cancer induced by 1,2-dimethylhydrazine in rats.柠檬桉（Curtis）Skeels 对二甲基肼诱导大鼠结肠癌的化学预防作用。
J Cancer Res Clin Oncol. 2019 Jun;145(6):1417-1426. doi: 10.1007/s00432-019-02905-3. Epub 2019 Mar 28.
3
Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice.
通过脂肪酸异构化和肠道微生物群调节抑制小鼠结直肠癌发生的进程。
Gut Microbes. 2025 Dec;17(1):2464945. doi: 10.1080/19490976.2025.2464945. Epub 2025 Feb 9.
4
Selenium-Enriched Lactiplantibacillus plantarum ZZU 8-12 Regulates Intestinal Microbiota and Inhibits Acute Liver Injury.富硒植物乳杆菌ZZU 8-12调节肠道微生物群并抑制急性肝损伤。
Probiotics Antimicrob Proteins. 2025 Jan 28. doi: 10.1007/s12602-025-10459-9.
5
Matrine Alleviates Oxidative Stress and Inflammation in Colon Cancer by Activating the Nrf2 Pathway.苦参碱通过激活Nrf2信号通路减轻结肠癌中的氧化应激和炎症反应。
Turk J Gastroenterol. 2025 Jan 27;36(9):563-572. doi: 10.5152/tjg.2025.24438.
6
Inulin-based formulations as an emerging therapeutic strategy for cancer: A comprehensive review.基于菊粉的制剂作为癌症治疗的一种新兴策略：全面综述。
Int J Biol Macromol. 2024 Feb;259(Pt 1):129216. doi: 10.1016/j.ijbiomac.2024.129216. Epub 2024 Jan 5.
7
Using dietary fiber as stabilizer in dairy products: β-glucan and inulin-type fructans.在乳制品中使用膳食纤维作为稳定剂：β-葡聚糖和菊粉型果聚糖。
J Food Sci Technol. 2023 Dec;60(12):2945-2954. doi: 10.1007/s13197-022-05651-6. Epub 2022 Dec 7.
8
Association between Probiotics and Modulation of Gut Microbial Community Composition in Colorectal Cancer Animal Models: A Systematic Review (2010-2021).益生菌与结直肠癌动物模型中肠道微生物群落组成调节之间的关联：一项系统综述（2010 - 2021年）
Can J Infect Dis Med Microbiol. 2023 Sep 9;2023:3571184. doi: 10.1155/2023/3571184. eCollection 2023.
9
Immunomodulatory effects of inulin and its intestinal metabolites.菊粉及其肠道代谢产物的免疫调节作用。
Front Immunol. 2023 Aug 10;14:1224092. doi: 10.3389/fimmu.2023.1224092. eCollection 2023.
10
Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.Panx1 基因敲除促进化学诱导的小鼠结肠癌发生前异型隐窝灶的发展。
Int J Exp Pathol. 2023 Dec;104(6):304-312. doi: 10.1111/iep.12491. Epub 2023 Aug 18.
由于小鼠缺乏细胞因子信号传导抑制因子-1，在炎症背景下肠道微生物群的失调
Inflamm Intest Dis. 2019 Feb;3(3):145-154. doi: 10.1159/000495462. Epub 2019 Jan 10.
4
Isoquercetin and inulin synergistically modulate the gut microbiome to prevent development of the metabolic syndrome in mice fed a high fat diet.槲皮素和菊粉协同调节肠道微生物群，防止高脂肪饮食喂养的小鼠代谢综合征的发展。
Sci Rep. 2018 Jul 4;8(1):10100. doi: 10.1038/s41598-018-28521-8.
5
Probiotics in the treatment of chronic kidney disease: a systematic review.益生菌治疗慢性肾脏病：一项系统评价
J Bras Nefrol. 2018 Jul-Sep;40(3):278-286. doi: 10.1590/2175-8239-jbn-3931. Epub 2018 Jun 21.
6
Phytic acid improves intestinal mucosal barrier damage and reduces serum levels of proinflammatory cytokines in a 1,2-dimethylhydrazine-induced rat colorectal cancer model.植酸可改善 1,2-二甲基肼诱导的大鼠结直肠肿瘤模型的肠道黏膜屏障损伤，并降低促炎细胞因子的血清水平。
Br J Nutr. 2018 Jul;120(2):121-130. doi: 10.1017/S0007114518001290.
7
Anticancer potential against cervix cancer (HeLa) cell line of probiotic Lactobacillus casei and Lactobacillus paracasei strains isolated from human breast milk.从人乳中分离的益生菌干酪乳杆菌和副干酪乳杆菌菌株对宫颈癌（HeLa）细胞系的抗癌潜力。
Food Funct. 2018 May 23;9(5):2705-2715. doi: 10.1039/c8fo00547h.
8
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice.益生菌补充剂通过改变微生物群减少了结肠炎相关结肠癌在小鼠中的发生。
World J Gastroenterol. 2018 May 14;24(18):1995-2008. doi: 10.3748/wjg.v24.i18.1995.
9
Strain Shirota Enhances the In Vitro Antiproliferative Effect of Geniposide in Human Oral Squamous Carcinoma HSC-3 Cells.Shirota 株菌增强栀子苷对人口腔鳞癌细胞 HSC-3 的体外增殖抑制作用。
Molecules. 2018 May 3;23(5):1069. doi: 10.3390/molecules23051069.
10
Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.拟杆菌属减弱 Toll 样受体 4 信号和 Akt 激活，并阻断高脂肪饮食喂养的氧化偶氮甲烷处理小鼠的结肠肿瘤形成。
Int J Cancer. 2018 Oct 1;143(7):1797-1805. doi: 10.1002/ijc.31559.