富硒植物乳杆菌ZZU 8-12调节肠道微生物群并抑制急性肝损伤。
Selenium-Enriched Lactiplantibacillus plantarum ZZU 8-12 Regulates Intestinal Microbiota and Inhibits Acute Liver Injury.
作者信息
Wang Yanping, Ma Hengyu, Li Haolong, Huang Yuhang, Tang Yupeng, Tang Xiaoxue, Sun Pintian, Tan Zhongfang, Pang Huili, Yang Fengyuan
机构信息
Henan Key Laboratory of Ion Beam Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China.
Department of Medical Equipment, Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, 450000, Zhengzhou, China.
出版信息
Probiotics Antimicrob Proteins. 2025 Jan 28. doi: 10.1007/s12602-025-10459-9.
Intake of certain Lactiplantibacillus strains was recognized as a potential strategy for acute liver injury (ALI) prevention. This study is aimed at developing a selenium-enriched Lactiplantibacillus strain-based ALI prevention strategy. L. plantarum ZZU 8-12 was isolated from human fecal sample and screened out based on its adaption to intestinal microenvironment, inhibitive capability against pathogenic bacteria, and in vivo anti-inflammation response in DSS-induced colitis mice model. The strain was applied as a producer of nano selenium particles to produce selenium-enriched L. plantarum ZZU 8-12. Intake of selenium-enriched L. plantarum ZZU 8-12 upregulated the abundance of short-chain fatty acid-producing genera including Lactiplantibacillus, Phascolarctobacterium, Butyricicoccus, and Clostridiales bacterium in fecal microbiota and thus inhibited ALI induced by CCL injection in mice. This study drew the potential for selenium-enriched L. plantarum ZZU 8-12 as an ingredient for ALI protection.
摄入某些植物乳杆菌菌株被认为是预防急性肝损伤（ALI）的一种潜在策略。本研究旨在开发一种基于富硒植物乳杆菌菌株的ALI预防策略。植物乳杆菌ZZU 8-12从人类粪便样本中分离出来，并根据其对肠道微环境的适应性、对病原菌的抑制能力以及在DSS诱导的结肠炎小鼠模型中的体内抗炎反应进行筛选。该菌株被用作纳米硒颗粒的生产者，以生产富硒植物乳杆菌ZZU 8-12。摄入富硒植物乳杆菌ZZU 8-12上调了粪便微生物群中包括植物乳杆菌、袋熊杆菌、丁酸球菌和梭菌属细菌在内的短链脂肪酸产生菌属的丰度，从而抑制了小鼠注射CCL诱导的ALI。本研究揭示了富硒植物乳杆菌ZZU 8-12作为ALI保护成分的潜力。
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