Robbertse Pieter-Paul S, Doubell Anton F, Nachega Jean B, Herbst Philip G
Division of Cardiology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Academic Hospital, Tygerberg, South Africa.
Department of Medicine and Centre for Infectious Diseases, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
SA Heart J. 2021 Oct 27;18(2):126-135.
HIV-associated cardiomyopathy (HIVAC) is a poorly understood group of diseases with a poor prognosis once ventricular dysfunction is present. Cardiovascular magnetic resonance has revealed a previously unappreciated burden of asymptomatic myocardial abnormalities in people living with HIV, including abnormalities already present at the time of HIV diagnosis. These abnormalities include thickened, inflamed ventricles that bear resemblance to cases of symptomatic HIVAC that are reported on in this article. Our understanding and the significance of asymptomatic HIV-associated myocardial pathology will be explored as early disease on a continuum towards more advanced cardiomyopathy. The need for prospective research in persons naïve to anti-retroviral therapy is emphasised as it may provide key findings to better understand this elusive disease process.
人类免疫缺陷病毒相关性心肌病（HIVAC）是一组了解甚少的疾病，一旦出现心室功能障碍，预后较差。心血管磁共振成像显示，感染艾滋病毒的人群中存在此前未被认识到的无症状心肌异常负担，包括在艾滋病毒诊断时就已存在的异常。这些异常包括心室增厚、发炎，与本文报道的有症状HIVAC病例相似。我们将探讨无症状HIV相关性心肌病变的理解及其意义，将其视为朝着更晚期心肌病发展的连续过程中的早期疾病。强调了对未接受抗逆转录病毒治疗的人群进行前瞻性研究的必要性，因为这可能提供关键发现，以更好地理解这一难以捉摸的疾病过程。
