Mao Zhou, Li Jialiang, Huang Wenjie, Jiang Hao, Zimba Bhahat Lawlley, Chen Li, Wan Jiangling, Wu Qingzhi
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology Wuhan 430070 China
School of Chemistry & Chemical Engineering, Shangdong University of Technology Zibo 255049 China.
RSC Adv. 2018 May 4;8(30):16619-16625. doi: 10.1039/c8ra01565a. eCollection 2018 May 3.
Nanofiber membranes display promising potential in biomedical fields, especially as scaffolds for drug delivery and tissue engineering. The structures and components of nanofibers play crucial roles in improving the mechanical properties and drug-releasing performance of nanofiber membranes. In this work, poly(lactic acid) (PLA)/graphene oxide (GO) nanofiber membranes with different structures (single-axial and co-axial structure) were prepared by electrospinning. The morphologies, structures, and mechanical properties of the as-prepared nanofiber membranes were characterized and compared. Furthermore, the drug-releasing performance of the as-prepared nanofiber membranes with different structures was evaluated by using an organic dye (Rhodamine B, RhB) as a drug model. Results show that the addition of GO not only significantly improved the thermal stability and mechanical properties of the PLA nanofiber membranes, but also promoted the cumulative release and release rate of RhB from nanofiber membranes. At the same GO concentration, the nanofiber membrane with the co-axial structure displayed a higher tensile strength and Young's modulus, but exhibited a lower cumulative release and release rate. The formation of the co-axial structure is beneficial in suppressing the initial burst release of RhB from nanofiber membranes.
纳米纤维膜在生物医学领域显示出广阔的应用前景，尤其是作为药物递送和组织工程的支架。纳米纤维的结构和成分在改善纳米纤维膜的机械性能和药物释放性能方面起着关键作用。在这项工作中，通过静电纺丝制备了具有不同结构（单轴和同轴结构）的聚乳酸（PLA）/氧化石墨烯（GO）纳米纤维膜。对制备的纳米纤维膜的形貌、结构和机械性能进行了表征和比较。此外，以有机染料罗丹明B（RhB）为药物模型，评估了不同结构的制备纳米纤维膜的药物释放性能。结果表明，GO的加入不仅显著提高了PLA纳米纤维膜的热稳定性和机械性能，还促进了RhB从纳米纤维膜中的累积释放和释放速率。在相同的GO浓度下，具有同轴结构的纳米纤维膜表现出更高的拉伸强度和杨氏模量，但累积释放量和释放速率较低。同轴结构的形成有利于抑制RhB从纳米纤维膜中的初始突释。
