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血清白细胞介素（IL-1、IL-2、IL-4、IL-6、IL-8 和 IL-10）与 COVID-19 疾病严重程度的关系：系统评价和荟萃分析。

Associations between Serum Interleukins (IL-1, IL-2, IL-4, IL-6, IL-8, and IL-10) and Disease Severity of COVID-19: A Systematic Review and Meta-Analysis.

机构信息

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, China.

出版信息

Biomed Res Int. 2022 Apr 30;2022:2755246. doi: 10.1155/2022/2755246. eCollection 2022.

DOI:10.1155/2022/2755246
PMID:35540724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9079324/
Abstract

BACKGROUND

To investigate the association between interleukins (IL-1, IL-2, IL-4, IL-6, IL-8, and IL-10) and the disease severity of coronavirus disease 2019 (COVID-19).

MATERIALS AND METHODS

We systematically searched records investigating the role of interleukins (IL-1, IL-2, IL-4, IL-6, IL-8, and IL-10) in COVID-19 patients in Web of Science, Pubmed, and Embase through December 2020. Data were extracted and pooled, and the weighted mean difference (WMD) and its 95% confidence interval (CI) were calculated. The funnel plot and the nonparametric trim and fill method were used to visualize and adjust the publication bias.

RESULTS

In total, 61 studies enrolled 14,136 subjects (14,041 patients and 95 healthy subjects) were enrolled in this meta-analysis. Our results showed that serum IL-2, IL-4, IL-6, and IL-10 levels were elevated in COVID-19 patients compared to healthy controls, and IL-6, IL-8, and IL-10 levels were increased in severe COVID-19 cases compared to nonsevere patients. Additionally, the levels of IL-1, IL-6, and IL-8 were elevated in nonsurvivor patients compared to survivors. For patients in the intensive care unit (ICU), IL-6 and IL-8 levels were increased than that in non-ICU patients.

CONCLUSIONS

Elevated levels of IL-6, IL-8, and IL-10 were associated with the disease severity of COVID-19, and elevated levels of IL-1, IL-6, and IL-8 were related to the prognosis of COVID-19 patients, which could be used to evaluate COVID-19 patients' disease severity and prognosis.

摘要

背景

探讨白细胞介素（IL-1、IL-2、IL-4、IL-6、IL-8 和 IL-10）与 2019 年冠状病毒病（COVID-19）疾病严重程度的关系。

材料与方法

我们系统地检索了 Web of Science、Pubmed 和 Embase 中调查白细胞介素（IL-1、IL-2、IL-4、IL-6、IL-8 和 IL-10）在 COVID-19 患者中作用的记录，检索时间截至 2020 年 12 月。提取并汇总数据，计算加权均数差（WMD）及其 95%置信区间（CI）。使用漏斗图和非参数修剪和填充方法来可视化和调整发表偏倚。

结果

共有 61 项研究纳入了 14136 名受试者（14041 名患者和 95 名健康受试者），这些研究纳入了本 meta 分析。我们的结果表明，与健康对照组相比，COVID-19 患者的血清 IL-2、IL-4、IL-6 和 IL-10 水平升高，与非重症患者相比，重症 COVID-19 患者的 IL-6、IL-8 和 IL-10 水平升高。此外，与幸存者相比，非幸存者患者的 IL-1、IL-6 和 IL-8 水平升高。对于 ICU 患者，IL-6 和 IL-8 水平高于非 ICU 患者。

结论

IL-6、IL-8 和 IL-10 水平升高与 COVID-19 疾病严重程度相关，IL-1、IL-6 和 IL-8 水平升高与 COVID-19 患者的预后相关，可用于评估 COVID-19 患者的疾病严重程度和预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2602/9079324/b3204e3d923d/BMRI2022-2755246.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2602/9079324/c763e27f9df6/BMRI2022-2755246.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2602/9079324/169f0f3a7a5e/BMRI2022-2755246.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2602/9079324/b3204e3d923d/BMRI2022-2755246.008.jpg

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