Ladanov Mikhail, Cheemalapati Surya, Wang Hao, Yuan Yuan, Koria Piyush, Pyayt Anna
Department of Chemical and Biomedical Engineering, University of South Florida Tampa FL 33647 USA
RSC Adv. 2018 Jan 11;8(5):2660-2666. doi: 10.1039/c7ra08276b. eCollection 2018 Jan 9.
Noble metal nanoparticles have been extensively studied as photo-sensitive agents for photothermal cancer therapy. Precise control over the size and shape of the nanoparticles allowed strong optical absorption and efficient heat generation necessary for destroying a tumor to be achieved. However, one of the fundamental challenges of application of the nanoparticles towards photothermal cancer therapy is low specificity in the targeting tumor tissue in comparison with the healthy tissue and the resulting unfavorable biodistribution of the nanoparticles. Additional levels of control over particle distribution can be achieved by making the particles magnetic and using external magnets to control their accumulation in a tumor. Since the direct synthesis of particles with a magnetic core and a metallic shell limits the options for design and fine-tuning of plasmonic properties, the alternative approaches to the design of such materials have to be investigated. Here we propose and demonstrate a new design of a hybrid plasmono-magnetic material for photothermal heating created by grafting Au nanocages onto a surface of magnetic micro-beads. Next, we confirm its dual functionality in studies and show that individual hybrid particles can be magnetically controlled with a precision of a few micrometers and precisely destroy individual cells using plasmonic heating.
贵金属纳米颗粒作为用于光热癌症治疗的光敏剂已得到广泛研究。对纳米颗粒尺寸和形状的精确控制使得实现破坏肿瘤所需的强光学吸收和高效热生成成为可能。然而，纳米颗粒应用于光热癌症治疗的一个基本挑战是，与健康组织相比，靶向肿瘤组织的特异性较低，以及由此导致的纳米颗粒不良生物分布。通过使颗粒具有磁性并使用外部磁体来控制它们在肿瘤中的积累，可以实现对颗粒分布的额外控制水平。由于直接合成具有磁芯和金属壳的颗粒限制了等离子体性质设计和微调的选择，因此必须研究设计此类材料的替代方法。在这里，我们提出并展示了一种用于光热加热的混合等离子体 - 磁性材料的新设计，该材料通过将金纳米笼接枝到磁性微珠表面而制成。接下来，我们在研究中证实了其双重功能，并表明单个混合颗粒可以以几微米的精度进行磁控，并使用等离子体加热精确破坏单个细胞。
