Mobed Ahmad, Malehmir Shirin, Ahmad Alipour Ali, Azizimoghaddam Yasaman, Sarabi Hediyeh Saghi, Ghazi Farhood
Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center of Psychiatry and Behavioral Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnol Lett. 2022 Jun;44(5-6):683-701. doi: 10.1007/s10529-022-03257-8. Epub 2022 May 11.
Cancer is undoubtedly one of the major human challenges worldwide. A number of pathogenic bacteria are deemed to be potentially associated with the disease. Accordingly, accurate and specific identification of cancer-associated bacteria can play an important role in cancer control and prevention. A variety of conventional methods such as culture, serology, and molecular-based methods as well as PCR and real-time PCR have been adopted to identify bacteria. However, supply costs, machinery fees, training expenses, consuming time, and the need for advanced equipment are the main problems with the old methods. As a result, advanced and modern techniques are being developed to overcome the disadvantages of conventional methods. Biosensor technology is one of the innovative methods that has been the focus of researchers due to its numerous advantages. The main purpose of this study is to provide an overview of the latest developed biosensors for recognizing the paramount cancer-associated bacteria.
癌症无疑是全球人类面临的主要挑战之一。许多致病细菌被认为可能与该疾病有关。因此,准确、特异性地鉴定与癌症相关的细菌在癌症控制和预防中可发挥重要作用。人们采用了多种传统方法来鉴定细菌,如培养法、血清学法、基于分子的方法以及聚合酶链反应(PCR)和实时荧光定量PCR。然而,供应成本、设备费用、培训开支、耗时以及对先进设备的需求是这些旧方法的主要问题。因此,正在开发先进的现代技术以克服传统方法的缺点。生物传感器技术是一种创新方法,因其众多优点而成为研究人员关注的焦点。本研究的主要目的是概述最新开发的用于识别最重要的癌症相关细菌的生物传感器。