Air-assisted ionic liquid dispersive liquid-liquid microextraction based on solidification of the aqueous phase for the determination of triazole fungicides in water samples by high-performance liquid chromatography.

A simple, rapid, and environmentally friendly approach was introduced to determine triazole fungicides in water samples by air-assisted ionic liquid dispersive liquid-liquid microextraction based on solidification of the aqueous phase using high-performance liquid chromatography-diode array detection. Ionic liquid was applied as the extraction solvent rather than a high-toxicity extraction solvent. The air-assisted dispersion method induced a trace amount of the ionic liquid to disperse as small droplets in the water sample, which significantly increased the contact area between the organic phase and the aqueous phase for the rapid transfer of target fungicides without using a dispersion solvent or auxiliary extraction devices. The solidification of the aqueous phase facilitated the collection of extraction solvent. The type of extraction solvent, the volume ratio of the extraction solvent to the water sample, the number of extraction cycles, the addition of NaCl, and pH values were evaluated. The recoveries were 72.65-100.13% with a relative standard deviation of 0.92% to 5.99%. The limits of quantification varied from 0.65 ng mL to 1.83 ng mL. This approach can be used to determine fungicides in ground, river, and lake water samples.