Tabesh Elham, Soheilipour Maryam, Sami Ramin, Mansourian Marjan, Tabesh Faezeh, Soltaninejad Forogh, Dehghan Mehrnegar, Nikgoftar Niloofar, Gharavinia Ali, Ghasemi Khojasteh, Adibi Peyman
Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pulmonology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2022 Apr 15;27:32. doi: 10.4103/jrms.jrms_641_21. eCollection 2022.
In this study, we summarized the data on gastrointestinal (GI) involvement and the potential association with clinical outcomes among the patients admitted to Khorshid Hospital.
We investigated 1113 inpatients (≥18 years old) diagnosed with coronavirus disease-2019 (COVID-19) from March to June 2020 in Khorshid Hospital. We collected demographic details, clinical information, vital signs, laboratory data, treatment type, and clinical outcomes from patients' medical records. The data of patients with GI symptoms were compared with those without GI symptoms.
A total of 1113 patients were recruited (male = 648). GI symptoms were observed in 612 (56.8%) patients (male = 329), the most common of which were nausea 387 (34.7%), followed by diarrhea 286 (25.7%), vomiting 260 (23.4%), and abdominal pain 168 (15.0%). The most prominent non-GI symptoms were cough 796 (71.5%), fever 792 (71.2%), shortness of breath 653 (58.7%), and body pain 591 (53.1%). The number of patients who were discharged, died, and were admitted to intensive care unit was significantly different in groups on the basis of GI and non-GI symptoms ( = 0.002, 0.009, 0.003).
While COVID-19 was predominantly diagnosed in males, GI symptoms were more commonly reported by females. The results indicated that GI symptoms in COVID-19 patients are common, and the symptoms are not correlated with the severity of the disease. Moreover, the presence of GI symptoms was positively related to milder disease. Among COVID-19 positive patients, the clinical outcomes of the GI group were promising, compared to those of non-GI group.
在本研究中，我们总结了霍尔希德医院收治患者的胃肠道（GI）受累情况以及与临床结局的潜在关联。
我们调查了2020年3月至6月期间在霍尔希德医院确诊为2019冠状病毒病（COVID-19）的1113名住院患者（≥18岁）。我们从患者的病历中收集了人口统计学细节、临床信息、生命体征、实验室数据、治疗类型和临床结局。将有胃肠道症状的患者数据与无胃肠道症状的患者数据进行比较。
共招募了1113名患者（男性=648名）。612名（56.8%）患者出现胃肠道症状（男性=329名），最常见的症状是恶心387例（34.7%），其次是腹泻286例（25.7%）、呕吐260例（23.4%）和腹痛168例（15.0%）。最突出的非胃肠道症状是咳嗽796例（71.5%）、发热792例（71.2%）、呼吸急促653例（58.7%）和身体疼痛591例（53.1%）。根据胃肠道和非胃肠道症状分组，出院、死亡和入住重症监护病房的患者人数有显著差异（P=0.002、0.009、0.003）。
虽然COVID-19主要在男性中被诊断出来，但女性更常报告胃肠道症状。结果表明，COVID-19患者的胃肠道症状很常见，且这些症状与疾病严重程度无关。此外，胃肠道症状的出现与病情较轻呈正相关。在COVID-19阳性患者中，与非胃肠道组相比，胃肠道组的临床结局较好。
