Department of Medical Microbiology, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Molecules. 2022 May 6;27(9):2995. doi: 10.3390/molecules27092995.
Just over a million people died globally in 2019 due to antibiotic resistance caused by ESKAPE pathogens (, , , , , and species). The World Health Organization (WHO) also lists antibiotic-resistant and as bacteria that pose the greatest threat to human health. As it is becoming increasingly difficult to discover new antibiotics, new alternatives are needed to solve the crisis of antimicrobial resistance (AMR). Bacteria commonly found in complex communities enclosed within self-produced matrices called biofilms are difficult to eradicate and develop increased stress and antimicrobial tolerance. This review summarises the role of antimicrobial peptides (AMPs) in combating the silent pandemic of AMR and their application in clinical medicine, focusing on both the advantages and disadvantages of AMPs as antibiofilm agents. It is known that many AMPs display broad-spectrum antimicrobial activities, but in a variety of organisms AMPs are not stable (short half-life) or have some toxic side effects. Hence, it is also important to develop new AMP analogues for their potential use as drug candidates. The use of one health approach along with developing novel therapies using phages and breakthroughs in novel antimicrobial peptide synthesis can help us in tackling the problem of AMR.
2019 年，全球有超过 100 万人死于抗生素耐药性导致的 ESKAPE 病原体（肠杆菌科、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和艰难梭菌）感染。世界卫生组织（WHO）还将耐抗生素的 和 列为对人类健康构成最大威胁的细菌。由于发现新抗生素变得越来越困难，因此需要新的替代品来解决抗菌药物耐药性（AMR）危机。通常在自我产生的基质（称为生物膜）内的复杂群落中发现的细菌难以消除，并产生更大的压力和抗菌药物耐受性。这篇综述总结了抗菌肽（AMPs）在对抗 AMR 这一无声大流行中的作用及其在临床医学中的应用，重点介绍了 AMPs 作为抗生物膜剂的优缺点。众所周知，许多 AMPs 具有广谱抗菌活性，但在许多生物体中，AMPs 不稳定（半衰期短）或具有一些毒性副作用。因此，开发新的 AMP 类似物作为潜在的药物候选物也很重要。采用一种健康方法，结合使用噬菌体开发新型疗法和新型抗菌肽合成方面的突破，可以帮助我们解决 AMR 问题。
