Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK.
Molecular Immunity Unit, University of Cambridge Department of Medicine, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, UK; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK.
Curr Opin Immunol. 2022 Jun;76:102188. doi: 10.1016/j.coi.2022.102188. Epub 2022 May 12.
The meninges encase the brain and spinal cord and house a variety of immune cells, including developing and mature B cells, and antibody-secreting plasma cells. In homeostasis, these cells localize around the dural venous sinuses, providing a defense 'zone' to protect the brain and spinal cord from blood-borne pathogens. Dural plasma cells predominantly secrete IgA antibodies, and some originate from the gastrointestinal tract, with the number and antibody isotype shaped by the gut microbiome. For developing B cells arriving from the adjacent bone marrow, the dura provides a site to tolerize against central nervous system antigens. In this review, we will discuss our current understanding of meningeal humoral immunity in homeostasis.
脑膜包裹着大脑和脊髓，其中容纳着多种免疫细胞，包括正在发育和成熟的 B 细胞以及分泌抗体的浆细胞。在体内平衡状态下，这些细胞定位于硬脑膜窦周围，为大脑和脊髓提供了一个防御“区”，以防止血源性病原体的侵袭。硬脑膜浆细胞主要分泌 IgA 抗体，其中一些来源于胃肠道，其数量和抗体同型受肠道微生物组的影响。对于从相邻骨髓中迁移而来的发育中的 B 细胞，硬脑膜为其提供了对中枢神经系统抗原产生耐受的部位。在这篇综述中，我们将讨论目前对脑膜体液免疫在体内平衡状态下的理解。
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