Specialty in Endodontics, Faculty of Dentistry, University of Cuenca, Ecuador; Full Professor, Discipline of Endodontics, Faculty of Dentistry, University of Cuenca, Ecuador.
Specialty in Endodontics, Faculty of Dentistry, University of Cuenca, Ecuador.
J Endod. 2022 Aug;48(8):1005-1019. doi: 10.1016/j.joen.2022.05.004. Epub 2022 May 14.
Dental pulp fibroblasts (DPFs) are the most abundant cell type in the dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in the repair and maintenance of this connective tissue.
We used the search terms "pulp fibroblast," "complement system proteins," "pulp inflammation," "angiogenesis," and "dentin pulp regeneration" to identify articles from the PubMed and Scopus databases.
These sentinel cells produce all complement system proteins participating in defense processes, control of inflammation, and dentin-pulp regeneration; produce several proinflammatory cytokines and chemokines and express pattern-recognition receptors, demonstrating their involvement in immunoregulatory mechanisms; express neuropeptides and their receptors, playing an important role in neurogenic inflammation and dental pulp wound healing; secrete angiogenic growth factors as well as neurotrophic proteins, essential for dentin-pulp regeneration; regulate neuronal plasticity processes; and can sense the external environment.
This review highlights that DPFs are more than mere passive cells in pulp biology and presents an integrative analysis of their roles and functions.
牙髓成纤维细胞（DFP）是牙髓中最丰富的细胞类型。它们发挥着关键作用；然而，人们常常错误地认为它们只参与这种结缔组织的修复和维持。
我们使用了“牙髓成纤维细胞”、“补体系统蛋白”、“牙髓炎症”、“血管生成”和“牙本质牙髓再生”等检索词，从 PubMed 和 Scopus 数据库中确定了文章。
这些哨兵细胞产生参与防御过程、控制炎症和牙本质-牙髓再生的所有补体系统蛋白；产生几种促炎细胞因子和趋化因子，并表达模式识别受体，表明它们参与免疫调节机制；表达神经肽及其受体，在神经原性炎症和牙髓创伤愈合中发挥重要作用；分泌血管生成生长因子和神经营养蛋白，对牙本质-牙髓再生至关重要；调节神经元可塑性过程；并能感知外部环境。
本综述强调了 DFP 在牙髓生物学中不仅仅是被动细胞，并对其作用和功能进行了综合分析。
