Laboratory of Theoretical and Computational Nanoscience, CAS Key Laboratory of Nanophotonic Materials and Devices, CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2022 Jul;11(14):e2200841. doi: 10.1002/adhm.202200841. Epub 2022 May 27.
Nanomaterials as T /T dual-mode magnetic resonance imaging (MRI) contrast agents have great potential in improving the accuracy of tumor diagnosis. Applications of such materials, however, are limited by the complicated chemical synthesis process and potential biosafety issues. In this study, the biosynthesis of manganese (Mn)-doped magnetosomes (MagMn) that not only can be used in T /T dual-mode MR imaging with self-confirmation for tumor detection, but also improve the photothermal conversion efficiency for MRI-guided photothermal therapy (PTT) is reported. The MagMn nanoparticles (NPs) are naturally produced through the biomineralization of magnetotactic bacteria by doping Mn into the ferromagnetic iron oxide crystals. In vitro and in vivo studies demonstrated that targeting peptides functionalized MagMn enhanced both T and T MRI signals in tumor tissue and significantly inhibited tumor growth by the further MRI-guided PTT. It is envisioned that the biosynthesized multifunctional MagMn nanoplatform may serve as a potential theranostic agent for cancer diagnosis and treatment.
纳米材料作为 T/T 双模磁共振成像（MRI）对比剂，在提高肿瘤诊断准确性方面具有巨大潜力。然而，这类材料的应用受到复杂的化学合成工艺和潜在生物安全性问题的限制。在这项研究中，报告了通过生物矿化方法合成锰（Mn）掺杂磁小体（MagMn），其不仅可用于 T/T 双模 MRI 成像，并具有肿瘤检测的自我确认能力，还能提高磁共振成像引导光热治疗（PTT）的光热转换效率。MagMn 纳米颗粒（NPs）是通过将 Mn 掺杂到铁磁性氧化铁晶体中，由趋磁细菌的生物矿化作用自然产生的。体外和体内研究表明，靶向肽功能化的 MagMn 增强了肿瘤组织中的 T1 和 T2 MRI 信号，并通过进一步的 MRI 引导 PTT 显著抑制了肿瘤生长。可以预见，生物合成的多功能 MagMn 纳米平台可能成为癌症诊断和治疗的潜在治疗剂。
