Peng Zixin, Yan Lin, Yang Shuran, Yang Dajin
NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing, China.
China CDC Wkly. 2022 Jan 14;4(2):17-21. doi: 10.46234/ccdcw2021.277.
For a long time, () was thought to be a commensal strain in human and animal digestive tracts. However, over the past three decades, some unique clones rapidly acquired multiple antimicrobial resistance (AMR), which led these clones to survive hospital environments and become a hospital-adapted clonal complex (CC) 17. Since the adaptation of these clones to changes in habitat, vancomycin-resistant CC17 has emerged as the leading cause of hospital-acquired infections worldwide. This epidemic hospital-adapted lineage has diverged from other populations approximately 75 years ago. The CC17 lineage originated from animal strains, but not human commensal lines. We reviewed the evolutionary progress and the molecular mechanisms of CC17 from a gut commensal to a multi-antimicrobial resistant nosocomial pathogen.
长期以来，（）被认为是人和动物消化道中的共生菌株。然而，在过去三十年中，一些独特的克隆迅速获得了多重抗菌耐药性（AMR），这使得这些克隆能够在医院环境中存活，并形成了医院适应性克隆复合体（CC）17。自从这些克隆适应栖息地变化以来，耐万古霉素的CC17已成为全球医院获得性感染的主要原因。这种流行的医院适应性谱系大约在75年前就与其他种群分化开来。CC17谱系起源于动物菌株，而非人类共生菌株。我们回顾了CC17从肠道共生菌演变为多重抗菌耐药性医院病原体的进化过程和分子机制。
