School of Life Sciences, University of Nottingham, Nottingham, United Kingdom; email:
Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom; email:
Annu Rev Microbiol. 2022 Sep 8;76:113-134. doi: 10.1146/annurev-micro-041320-010046. Epub 2022 May 24.
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female mosquito vector. Cell division, proliferation, and invasion are essential for parasite development, transmission, and survival. Most research has focused on development in the vertebrate, which causes disease; however, knowledge of malaria parasite development in the mosquito (the sexual and transmission stages) is now rapidly accumulating, gathered largely through investigation of the rodent malaria model, with In this review, we discuss the seminal genome-wide screens that have uncovered key regulators of cell proliferation, invasion, and transmission during sexual development. Our focus is on the roles of transcription factors, reversible protein phosphorylation, and molecular motors. We also emphasize the still-unanswered important questions around key pathways in cell division during the vector transmission stages and how they may be targeted in future studies.
脊椎动物和雌性蚊子媒介。细胞分裂、增殖和入侵是寄生虫发育、传播和生存的关键。大多数研究都集中在导致疾病的脊椎动物发育上；然而，现在对蚊子（性和传播阶段）中疟原虫发育的了解正在迅速积累，主要通过对啮齿动物疟疾模型的研究来收集。在这篇综述中，我们讨论了大规模的全基因组筛选，这些筛选揭示了性发育过程中细胞增殖、入侵和传播的关键调控因子。我们的重点是转录因子、可逆蛋白磷酸化和分子马达的作用。我们还强调了在媒介传播阶段细胞分裂的关键途径中仍未解决的重要问题，以及它们如何在未来的研究中作为靶点。
