Hughes J R, Stone J L, Fino J J, Hart L A
Neurology. 1987 Apr;37(4):656-62. doi: 10.1212/wnl.37.4.656.
The goal of this study was to determine the relative usefulness of the flash (FL), pattern reversal (PR) of 56', and PR of 28' in 62 patients (pts) with either MS (34) or non-MS (28) compared with normals (19). An abnormal visual evoked potential was found in 58%, 69%, and 81% of the eyes tested in possible, probable, and definite MS and in 88% of the non-MS group. The 28' PR produced the most abnormal responses, the greatest number with either greater than 3 standard deviations (SD) from the mean or greater than 2 SD in both MS and non-MS groups. The FL was second best at producing the most abnormal responses, but more often produced the only abnormality (29), compared with 28' PR (11). The 56' PR produced the only abnormality in none of the MS pts and in only one of the non-MS pts. In all categories (most abnormal, greater than 3 SD, greater than 2 SD, the only abnormality of greater than 3 SD or greater than 2 SD, and other peaks abnormal), the 28' PR was usually by far the best stimulus for definite (and probable) MS, but equally as effective was the FL in the possible MS pts Our data suggest the usefulness of 28' and not 56' PR, but the FL is especially useful in pts with possible MS.
本研究的目的是确定闪光（FL）、56'图形翻转（PR）和28'PR在62例患有多发性硬化症（MS，34例）或非MS（28例）的患者中与19例正常对照相比的相对效用。在可能、很可能和确诊的MS患者以及88%的非MS组患者中，分别有58%、69%和81%的受试眼发现视觉诱发电位异常。在MS组和非MS组中，28'PR产生的异常反应最多，无论是高于均值3个标准差（SD）还是高于2个SD的数量均最多。FL产生异常反应的效果次之，但与28'PR（11例）相比，更常产生唯一的异常（29例）。56'PR在所有MS患者中均未产生唯一异常，在非MS患者中仅1例产生唯一异常。在所有类别（最异常、高于3SD、高于2SD、高于3SD或高于2SD的唯一异常以及其他峰值异常）中，28'PR通常是确诊（和很可能）MS的最佳刺激，但在可能患有MS的患者中，FL同样有效。我们的数据表明28'PR有用，而56'PR无用，但FL对可能患有MS的患者特别有用。
