Eteraf-Oskouei Tahereh, Najafi Moslem
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Medical Education Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2022 Mar;12(2):248-261. doi: 10.34172/apb.2022.026. Epub 2021 Feb 1.
Cancer was predicted as the leading cause of death and the most important obstacle to the increased life expectancy in the 21st century worldwide. The World Health Organization (WHO) estimated number of new cases of cancers in 2020 about 19 million, and this number is estimated to be more than 295300000 people up to 2040 (more than 55% increase during next 20 years). Standard treatments for cancer include surgery, radiotherapy, and chemotherapy. However, all of these methods have dangerous side effects, so researchers are more interested in finding novel and less risky therapies. In recent years, there has been a great deal of interest in the development of anticancer agents obtained from foods or natural products. The relative safety of natural and food-derived compounds makes them attractive alternatives to conventional cancer treatment drugs. As a result, the majority of people are advised to use complementary and alternative medicine to treat and prevent cancer. In recent years, honey, as a natural product, has attracted many researchers' attention as an alternative to conventional anticancer drugs. Natural honey has long been used as a medicine and nutrient and its beneficial effects on various diseases in animal and human models have been studied. It was found that it has a wide range of therapeutic properties, including antioxidant, antibacterial, antiviral, anti-fungal, anti-diabetic, anti-inflammatory, anti-hypertensive, antiarrhythmic, wound healing, and liver protection benefits. This article aimed to review the role of natural honey in the prevention and treatment of a number of important cancers and their subsequent complications.
癌症被预测为21世纪全球范围内的主要死因以及预期寿命增长的最重要障碍。世界卫生组织（WHO）估计2020年癌症新发病例约1900万，到2040年这一数字预计将超过2.953亿（未来20年增长超过55%）。癌症的标准治疗方法包括手术、放疗和化疗。然而，所有这些方法都有危险的副作用，因此研究人员更有兴趣寻找新颖且风险较小的疗法。近年来，人们对从食物或天然产物中获取的抗癌剂的开发产生了浓厚兴趣。天然和食物衍生化合物的相对安全性使其成为传统癌症治疗药物有吸引力的替代品。因此，大多数人被建议使用补充和替代医学来治疗和预防癌症。近年来，蜂蜜作为一种天然产物，作为传统抗癌药物的替代品吸引了许多研究人员的关注。天然蜂蜜长期以来一直被用作药物和营养物质，并且其对动物和人体模型中各种疾病的有益作用已得到研究。发现它具有广泛的治疗特性，包括抗氧化、抗菌、抗病毒、抗真菌、抗糖尿病、抗炎、抗高血压、抗心律失常、伤口愈合和肝脏保护作用。本文旨在综述天然蜂蜜在预防和治疗一些重要癌症及其后续并发症中的作用。
