The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran.
Int Immunopharmacol. 2022 Jul;108:108882. doi: 10.1016/j.intimp.2022.108882. Epub 2022 May 24.
Oncolytic viruses (OVs) harness the hallmarks of tumor cells and cancer-related immune responses for the lysis of malignant cells, modulation of the tumor microenvironment, and exertion of vaccine-like activities. However, efficient clinical exploitation of these potent therapeutic modules requires their systematic administration, especially against metastatic and solid tumors. Therefore, developing methods for shielding a virus from the neutralizing environment of the bloodstream while departing toward tumor sites is a must. This paper reports the latest advancements in the employment of chemical and biological compounds aimed at safe and efficient delivery of OVs to target tissues or tumor deposits within the host.
溶瘤病毒（OVs）利用肿瘤细胞的特征和与癌症相关的免疫反应来裂解恶性细胞、调节肿瘤微环境并发挥类似疫苗的作用。然而，要在临床上有效地利用这些强大的治疗模块，需要对其进行系统的管理，特别是针对转移性和实体瘤。因此，开发一种方法来保护病毒免受血液中中和环境的影响，同时使其向肿瘤部位转移是必要的。本文报告了最新的进展，即在使用化学和生物化合物方面的进展，旨在安全有效地将 OV 递送到宿主内的目标组织或肿瘤沉积物。
