Ashrit Priya, Sadanandan Bindu, Shetty Kalidas, Vaniyamparambath Vijayalakshmi
Department of Biotechnology, M S Ramaiah Institute of Technology, Bengaluru 560054, India.
Department of Plant Sciences, North Dakota State University, Fargo, ND 58105, USA.
Antibiotics (Basel). 2022 Apr 25;11(5):573. doi: 10.3390/antibiotics11050573.
The polymicrobial biofilm of with exhibits a dynamic interspecies interaction and is refractory to conventional antimicrobials. In this study, a high biofilm-forming multidrug-resistant strain of overcomes inhibition by in a 24 h coculture. However, following treatment with whole Aqueous Garlic Extract (AGE), these individual biofilms of multidrug-resistant M-207 and Ampicillin-resistant ATCC 39936 and their polymicrobial biofilm were prevented, as evidenced by biochemical and structural characterization. This study advances the antimicrobial potential of AGE to inhibit drug-resistant and bacterial-associated polymicrobial biofilms, suggesting the potential for effective combinatorial and synergistic antimicrobial designs with minimal side effects.
具有……的多微生物生物膜表现出动态的种间相互作用，并且对传统抗菌药物具有抗性。在本研究中，一株形成生物膜能力强的多重耐药菌株在24小时共培养中克服了……的抑制作用。然而，用大蒜全水提取物（AGE）处理后，多重耐药的……M - 207和耐氨苄西林的……ATCC 39936的这些单个生物膜及其多微生物生物膜受到了抑制，生化和结构表征证明了这一点。本研究提高了AGE抑制耐药菌和细菌相关多微生物生物膜的抗菌潜力，表明了具有最小副作用的有效联合和协同抗菌设计的潜力。 （原文部分内容缺失，翻译可能不太连贯）
