Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.
College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Medicina (Kaunas). 2022 May 20;58(5):680. doi: 10.3390/medicina58050680.
Measles is an RNA virus infectious disease mainly seen in children. Despite the availability of an effective vaccine against measles, it remains a health issue in children. Although it is a self-limiting disease, it becomes severe in undernourished and immune-compromised individuals. Measles infection is associated with secondary infections by opportunistic bacteria due to the immunosuppressive effects of the measles virus. Recent reports highlight that measles infection erases the already existing immune memory of various pathogens. This review covers the incidence, pathogenesis, measles variants, clinical presentations, secondary infections, elimination of measles virus on a global scale, and especially the immune responses related to measles infection.
麻疹是一种主要发生在儿童中的 RNA 病毒传染病。尽管有针对麻疹的有效疫苗，但它仍然是儿童健康问题。虽然它是一种自限性疾病，但在营养不良和免疫功能低下的个体中会变得严重。麻疹病毒的免疫抑制作用导致麻疹感染与机会性细菌的继发感染相关。最近的报告强调，麻疹感染会消除各种病原体已经存在的免疫记忆。这篇综述涵盖了麻疹的发病率、发病机制、麻疹变异体、临床表现、继发感染、在全球范围内消除麻疹病毒，特别是与麻疹感染相关的免疫反应。
