Popov Anton A, Tikhonowski Gleb V, Shakhov Pavel V, Popova-Kuznetsova Elena A, Tselikov Gleb I, Romanov Roman I, Markeev Andrey M, Klimentov Sergey M, Kabashin Andrei V
National Research Nuclear University MEPhI, 115409 Moscow, Russia.
Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia.
Nanomaterials (Basel). 2022 May 13;12(10):1672. doi: 10.3390/nano12101672.
Owing to a strong photothermal response in the near-IR spectral range and very low toxicity, titanium nitride (TiN) nanoparticles (NPs) synthesized by pulsed laser ablation in liquids (PLAL) present a novel appealing object for photo-induced therapy of cancer, but the properties of these NPs still require detailed investigation. Here, we have elaborated methods of femtosecond laser ablation from the TiN target in a variety of liquid solutions, including acetonitrile, dimethylformamide, acetone, water, and HO, to synthesize TiN NPs and clarify the effect of liquid type on the composition and properties of the formed NPs. The ablation in all solvents led to the formation of spherical NPs with a mean size depending on the liquid type, while the composition of the NPs ranged from partly oxidized TiN to almost pure TiO, which conditioned variations of plasmonic peak in the region of relative tissue transparency (670-700 nm). The degree of NP oxidation depended on the solvent, with much stronger oxidation for NPs prepared in aqueous solutions (especially in HO), while the ablation in organic solvents resulted in a partial formation of titanium carbides as by-products. The obtained results contribute to better understanding of the processes in reactive PLAL and can be used to design TiN NPs with desired properties for biomedical applications.
由于在近红外光谱范围内具有强烈的光热响应且毒性极低，通过液体中的脉冲激光烧蚀（PLAL）合成的氮化钛（TiN）纳米颗粒（NPs）成为癌症光诱导治疗中一种新型的有吸引力的对象，但这些纳米颗粒的性质仍需要详细研究。在此，我们阐述了在包括乙腈、二甲基甲酰胺、丙酮、水和过氧化氢在内的各种液体溶液中从TiN靶进行飞秒激光烧蚀的方法，以合成TiN纳米颗粒并阐明液体类型对所形成纳米颗粒的组成和性质的影响。在所有溶剂中的烧蚀都导致形成平均尺寸取决于液体类型的球形纳米颗粒，而纳米颗粒的组成范围从部分氧化的TiN到几乎纯的TiO，这决定了在相对组织透明区域（670 - 700 nm）等离子体峰的变化。纳米颗粒的氧化程度取决于溶剂，在水溶液（特别是过氧化氢）中制备的纳米颗粒氧化程度要强得多，而在有机溶剂中的烧蚀会导致副产物碳化钛的部分形成。所得结果有助于更好地理解反应性PLAL中的过程，并可用于设计具有所需性质的TiN纳米颗粒用于生物医学应用。
